An analytical method based on liquid chromatography-tandem mass spectrometry (LC-MS-MS) has been developed for the determination of pharmaceutical compounds in water samples. The drugs investigated were the analgesics: Ibuprofen, Fenoprofen, Ketoprofen, Naproxen, and Diclofenac and the decomposition product of acetylsalicylic acid: salicylic acid. The selected compounds are acidic, very polar and all are analgesic compounds that can be purchased without medical prescription. Sample enrichment of water samples was achieved by solid-phase extraction procedure (SPE), using Waters Oasis HLB cartridges followed by LC-MS-MS. A narrow-bore 2.1 min i.d., reversed phase LC C-18 column was used to chromatograph analytes. Average recoveries from 1 L samples varied 75-95% and the detection limits are <1 ng L-1. The method developed was applied to real samples from wastewater and surface waters of Lazio country (Italy).
DETERMINATION OF NON STEROIDAL ANTI-INFLAMMATORY DRUGS IN SURFACE WATER AND WASTEWATER BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY / Marchese, Stefano; Perret, Daniela; Gentili, Alessandra; Curini, Roberta; F., Pastori. - In: CHROMATOGRAPHIA. - ISSN 0009-5893. - STAMPA. - 58:5-6(2003), pp. 263-269. [10.1365/s10337-003-0052-4]
DETERMINATION OF NON STEROIDAL ANTI-INFLAMMATORY DRUGS IN SURFACE WATER AND WASTEWATER BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY
MARCHESE, Stefano;PERRET, Daniela;GENTILI, Alessandra;CURINI, Roberta;
2003
Abstract
An analytical method based on liquid chromatography-tandem mass spectrometry (LC-MS-MS) has been developed for the determination of pharmaceutical compounds in water samples. The drugs investigated were the analgesics: Ibuprofen, Fenoprofen, Ketoprofen, Naproxen, and Diclofenac and the decomposition product of acetylsalicylic acid: salicylic acid. The selected compounds are acidic, very polar and all are analgesic compounds that can be purchased without medical prescription. Sample enrichment of water samples was achieved by solid-phase extraction procedure (SPE), using Waters Oasis HLB cartridges followed by LC-MS-MS. A narrow-bore 2.1 min i.d., reversed phase LC C-18 column was used to chromatograph analytes. Average recoveries from 1 L samples varied 75-95% and the detection limits are <1 ng L-1. The method developed was applied to real samples from wastewater and surface waters of Lazio country (Italy).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
