An analytical method based on liquid chromatography-tandem mass spectrometry (LC-MS-MS) has been developed for the determination of pharmaceutical compounds in water samples. The drugs investigated were the analgesics: Ibuprofen, Fenoprofen, Ketoprofen, Naproxen, and Diclofenac and the decomposition product of acetylsalicylic acid: salicylic acid. The selected compounds are acidic, very polar and all are analgesic compounds that can be purchased without medical prescription. Sample enrichment of water samples was achieved by solid-phase extraction procedure (SPE), using Waters Oasis HLB cartridges followed by LC-MS-MS. A narrow-bore 2.1 min i.d., reversed phase LC C-18 column was used to chromatograph analytes. Average recoveries from 1 L samples varied 75-95% and the detection limits are <1 ng L-1. The method developed was applied to real samples from wastewater and surface waters of Lazio country (Italy).

DETERMINATION OF NON STEROIDAL ANTI-INFLAMMATORY DRUGS IN SURFACE WATER AND WASTEWATER BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY / Marchese, Stefano; Perret, Daniela; Gentili, Alessandra; Curini, Roberta; F., Pastori. - In: CHROMATOGRAPHIA. - ISSN 0009-5893. - STAMPA. - 58:5-6(2003), pp. 263-269. [10.1365/s10337-003-0052-4]

DETERMINATION OF NON STEROIDAL ANTI-INFLAMMATORY DRUGS IN SURFACE WATER AND WASTEWATER BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY

MARCHESE, Stefano;PERRET, Daniela;GENTILI, Alessandra;CURINI, Roberta;
2003

Abstract

An analytical method based on liquid chromatography-tandem mass spectrometry (LC-MS-MS) has been developed for the determination of pharmaceutical compounds in water samples. The drugs investigated were the analgesics: Ibuprofen, Fenoprofen, Ketoprofen, Naproxen, and Diclofenac and the decomposition product of acetylsalicylic acid: salicylic acid. The selected compounds are acidic, very polar and all are analgesic compounds that can be purchased without medical prescription. Sample enrichment of water samples was achieved by solid-phase extraction procedure (SPE), using Waters Oasis HLB cartridges followed by LC-MS-MS. A narrow-bore 2.1 min i.d., reversed phase LC C-18 column was used to chromatograph analytes. Average recoveries from 1 L samples varied 75-95% and the detection limits are <1 ng L-1. The method developed was applied to real samples from wastewater and surface waters of Lazio country (Italy).
2003
non-steroidal anti-inflammatory drugs; surface water analysis; LC-MS/MS
01 Pubblicazione su rivista::01a Articolo in rivista
DETERMINATION OF NON STEROIDAL ANTI-INFLAMMATORY DRUGS IN SURFACE WATER AND WASTEWATER BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY / Marchese, Stefano; Perret, Daniela; Gentili, Alessandra; Curini, Roberta; F., Pastori. - In: CHROMATOGRAPHIA. - ISSN 0009-5893. - STAMPA. - 58:5-6(2003), pp. 263-269. [10.1365/s10337-003-0052-4]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/254356
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