Quercetin (Q) and 3-O-acylquercetines, up to 100 microg/mL, did not show significant activity on selected gram-positive strains, gram-negative strains and yeasts. Conversely an interesting inhibitory activity on Candida rugosa lipase by Q and its esters (3-O-acylquercetines) which, in vivo, could play an important role against lipase producing microorganisms, was detected. In particular, 3-O-acyl-quercetines, being more active (IC(16)=10(-4)-10(-6) M) and more lipophilic, could be more effective than Q when applied to the skin or mucosae.
Antimicrobial and anti-lipase activity of quercetin and its C2-C16 3-O-acyl-esters / M. T., Gatto; S., Falcocchio; E., Grippa; Mazzanti, Gabriela; L., Battinelli; G., Nicolosi; D., Lambusta; Saso, Luciano. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - STAMPA. - 10:2(2002), pp. 269-272. [10.1016/S0968-0896(01)00275-9]
Antimicrobial and anti-lipase activity of quercetin and its C2-C16 3-O-acyl-esters
MAZZANTI, Gabriela;SASO, Luciano
2002
Abstract
Quercetin (Q) and 3-O-acylquercetines, up to 100 microg/mL, did not show significant activity on selected gram-positive strains, gram-negative strains and yeasts. Conversely an interesting inhibitory activity on Candida rugosa lipase by Q and its esters (3-O-acylquercetines) which, in vivo, could play an important role against lipase producing microorganisms, was detected. In particular, 3-O-acyl-quercetines, being more active (IC(16)=10(-4)-10(-6) M) and more lipophilic, could be more effective than Q when applied to the skin or mucosae.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
