Quercetin (Q) and 3-O-acylquercetines, up to 100 microg/mL, did not show significant activity on selected gram-positive strains, gram-negative strains and yeasts. Conversely an interesting inhibitory activity on Candida rugosa lipase by Q and its esters (3-O-acylquercetines) which, in vivo, could play an important role against lipase producing microorganisms, was detected. In particular, 3-O-acyl-quercetines, being more active (IC(16)=10(-4)-10(-6) M) and more lipophilic, could be more effective than Q when applied to the skin or mucosae.

Antimicrobial and anti-lipase activity of quercetin and its C2-C16 3-O-acyl-esters / M. T., Gatto; S., Falcocchio; E., Grippa; Mazzanti, Gabriela; L., Battinelli; G., Nicolosi; D., Lambusta; Saso, Luciano. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - STAMPA. - 10:2(2002), pp. 269-272. [10.1016/S0968-0896(01)00275-9]

Antimicrobial and anti-lipase activity of quercetin and its C2-C16 3-O-acyl-esters

MAZZANTI, Gabriela;SASO, Luciano
2002

Abstract

Quercetin (Q) and 3-O-acylquercetines, up to 100 microg/mL, did not show significant activity on selected gram-positive strains, gram-negative strains and yeasts. Conversely an interesting inhibitory activity on Candida rugosa lipase by Q and its esters (3-O-acylquercetines) which, in vivo, could play an important role against lipase producing microorganisms, was detected. In particular, 3-O-acyl-quercetines, being more active (IC(16)=10(-4)-10(-6) M) and more lipophilic, could be more effective than Q when applied to the skin or mucosae.
2002
CANDIDA-RUGOSA LIPASE; PHENOLIC-COMPOUNDS; FLAVONOIDS; ACNES
01 Pubblicazione su rivista::01a Articolo in rivista
Antimicrobial and anti-lipase activity of quercetin and its C2-C16 3-O-acyl-esters / M. T., Gatto; S., Falcocchio; E., Grippa; Mazzanti, Gabriela; L., Battinelli; G., Nicolosi; D., Lambusta; Saso, Luciano. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - STAMPA. - 10:2(2002), pp. 269-272. [10.1016/S0968-0896(01)00275-9]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/254347
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