Telomeres are structures functionally and structurally distinct from bulk chromatin. They are constituted of highly conserved 5-7 bp tandemly repeated units, organized into nucleosomes with short linkers, whereas the knowledge of the linker histone role in telomeric chromatin is still fragmentary. Experimental evidence suggests the structural organization of telomeric nucleosomes is different from that of the bulk chromatin. This work presents a systematic search of the telomeric nucleosome arrangements. A low-resolution molecular model was used to evaluate the relative nucleosome packing energy. Structures with favorable energy were found, reducing the possible telomeric chromatin conformations to two different three-dimensional folds. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Systematic search for compact structures of telomeric nucleosomes / Neva, Besker; Claudio, Anselmi; Raffaella, Paparcone; Scipioni, Anita; Maria, Savino; Pasquale De, Santis. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 554:3(2003), pp. 369-372. [10.1016/s0014-5793(03)01193-1]
Systematic search for compact structures of telomeric nucleosomes
SCIPIONI, Anita;
2003
Abstract
Telomeres are structures functionally and structurally distinct from bulk chromatin. They are constituted of highly conserved 5-7 bp tandemly repeated units, organized into nucleosomes with short linkers, whereas the knowledge of the linker histone role in telomeric chromatin is still fragmentary. Experimental evidence suggests the structural organization of telomeric nucleosomes is different from that of the bulk chromatin. This work presents a systematic search of the telomeric nucleosome arrangements. A low-resolution molecular model was used to evaluate the relative nucleosome packing energy. Structures with favorable energy were found, reducing the possible telomeric chromatin conformations to two different three-dimensional folds. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
