The study of the reactivity of 1,2-amino alcohols toward carbon dioxide in the presence of 2-pyrrolidone electro- generated base allowed to establish a new methodology for the synthesis of oxazolidin-2-ones. Chiral oxazolidin- 2-ones (Evans' chiral auxiliaries) were obtained in good to high yields avoiding the use of toxic, polluting or dangerous reagents. This methodology represents a further example of the direct employment of carbon dioxide as a source of carbon in organic synthesis.
The reaction of 1,2-amino alcohols with carbondioxide in the presence of 2-pyrrolidone electrogenerated base. New synthesis of chiral oxazolidin-2-ones / Casadei, Maria Antonietta; Feroci, Marta; Inesi, Achille; Rossi, L.; Sotgiu, G.. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - STAMPA. - 65:(2000), pp. 4759-4761. [10.1021/jo0002386]
The reaction of 1,2-amino alcohols with carbondioxide in the presence of 2-pyrrolidone electrogenerated base. New synthesis of chiral oxazolidin-2-ones
CASADEI, Maria Antonietta;FEROCI, Marta;INESI, ACHILLE;
2000
Abstract
The study of the reactivity of 1,2-amino alcohols toward carbon dioxide in the presence of 2-pyrrolidone electro- generated base allowed to establish a new methodology for the synthesis of oxazolidin-2-ones. Chiral oxazolidin- 2-ones (Evans' chiral auxiliaries) were obtained in good to high yields avoiding the use of toxic, polluting or dangerous reagents. This methodology represents a further example of the direct employment of carbon dioxide as a source of carbon in organic synthesis.File | Dimensione | Formato | |
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14. JOC 2000
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