Various bipyrryl analogues of bifonazole were synthesized starting from aryl-3-pyrryl-1-imidazolylmethanes. The introduction of a second pyrryl portion was performed by linking an acrylate moiety at 1-position of the pyrrole ring and then by treatment with TosMIC. The bipyrryl esters were hydrolyzed and decarboxylated to afford the required imidazoles. All new imidazole derivatives were tested against Candida albicans and Candida spp using as standard controls miconazole, bifonazole and ketoconazole.

ANTIFUNGAL AGENTS .8. SYNTHESIS AND ANTIFUNGAL ACTIVITIES OF BIPYRRYL ANALOGS OF BIFONAZOLE / DI SANTO, Roberto; Silvio, Massa; Costi, Roberta; Simonetti, Giovanna; Retico, Augusta; G., Apuzzo; F., Troccoli. - In: IL FARMACO. - ISSN 0014-827X. - STAMPA. - 49:(1994), pp. 229-236.

ANTIFUNGAL AGENTS .8. SYNTHESIS AND ANTIFUNGAL ACTIVITIES OF BIPYRRYL ANALOGS OF BIFONAZOLE

DI SANTO, Roberto;COSTI, Roberta;SIMONETTI, Giovanna;RETICO, Augusta;
1994

Abstract

Various bipyrryl analogues of bifonazole were synthesized starting from aryl-3-pyrryl-1-imidazolylmethanes. The introduction of a second pyrryl portion was performed by linking an acrylate moiety at 1-position of the pyrrole ring and then by treatment with TosMIC. The bipyrryl esters were hydrolyzed and decarboxylated to afford the required imidazoles. All new imidazole derivatives were tested against Candida albicans and Candida spp using as standard controls miconazole, bifonazole and ketoconazole.
1994
antifungal activity; antifungal agents; fungi; imidazoles; mycoses
01 Pubblicazione su rivista::01a Articolo in rivista
ANTIFUNGAL AGENTS .8. SYNTHESIS AND ANTIFUNGAL ACTIVITIES OF BIPYRRYL ANALOGS OF BIFONAZOLE / DI SANTO, Roberto; Silvio, Massa; Costi, Roberta; Simonetti, Giovanna; Retico, Augusta; G., Apuzzo; F., Troccoli. - In: IL FARMACO. - ISSN 0014-827X. - STAMPA. - 49:(1994), pp. 229-236.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/253762
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