To evaluate whether vertical HIV infection interferes with the expression of CD28 on T lymphocytes, 25 HIV-infected children and 29 seroreverted children born to HIV+ mothers were studied. The percentage of CD28- cells among CD8+ T lymphocytes was higher in HIV-infected children than in controls (P < 0.001). In fact, in HIV-infected children, this percentage was elevated from the first year of life, while in healthy seroreverted children, the proportion of CD28- cells among CD8+ cells rose progressively with age (r = 0.49; P = 0.008). In HIV+ children, the CD8+ CD28-, but not CD8+ CD28+ cell proportion was significantly correlated with immunological markers of disease progression, such as CD4+ cell loss (r = -0.65; P < 0.001) and the level of in vitro spontaneous lymphocyte apoptosis (r = 0.53; P = 0.03).

CD8+CD28-Tcells in vertically HIV-infected children / Brugnoni, D; Airo, P; Timpano, S; F., Malacarne; UGAZIO A., G; Cattaneo, R; Duse, Marzia. - In: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. - ISSN 0009-9104. - STAMPA. - 108:(1997), pp. 243-245. [10.1046/j.1365-2249.1997.4871386.x]

CD8+CD28-Tcells in vertically HIV-infected children

DUSE, MARZIA
1997

Abstract

To evaluate whether vertical HIV infection interferes with the expression of CD28 on T lymphocytes, 25 HIV-infected children and 29 seroreverted children born to HIV+ mothers were studied. The percentage of CD28- cells among CD8+ T lymphocytes was higher in HIV-infected children than in controls (P < 0.001). In fact, in HIV-infected children, this percentage was elevated from the first year of life, while in healthy seroreverted children, the proportion of CD28- cells among CD8+ cells rose progressively with age (r = 0.49; P = 0.008). In HIV+ children, the CD8+ CD28-, but not CD8+ CD28+ cell proportion was significantly correlated with immunological markers of disease progression, such as CD4+ cell loss (r = -0.65; P < 0.001) and the level of in vitro spontaneous lymphocyte apoptosis (r = 0.53; P = 0.03).
1997
01 Pubblicazione su rivista::01a Articolo in rivista
CD8+CD28-Tcells in vertically HIV-infected children / Brugnoni, D; Airo, P; Timpano, S; F., Malacarne; UGAZIO A., G; Cattaneo, R; Duse, Marzia. - In: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. - ISSN 0009-9104. - STAMPA. - 108:(1997), pp. 243-245. [10.1046/j.1365-2249.1997.4871386.x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/253728
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