A 99m Tc MIBI prone scintimammography (PSM) was performed in a case of underlying Pager's disease of the breast. 99m Tc MIBI PSM showed a diffuse scintigraphic image like a spl ead of uptake fr om the deeply located zones of the breast toward epidermis. In vivo, 99m Tc MIBI PSM represents the spread of neoplastic Paget's cells probably due to attracs induced by chemotactic factors released by keratinocytes. This spread in Paget's disease is correlated to neu oncogene overexpression which increases the metastatic activity as a consequence of motility enhancement and growth stimulation effect. These scintigraphic images suggest that 99m Te MIBI PSM could be relevant in management of Paget's disease of the breast.

99m Tc MIBI prone scintimammography in breast Paget's disease: A case report / Mezi, Silvia; Scopinaro, Francesco; A., Marzullo; E., Sallusti; David, Vincenzo; M., Ierardi; N. S., Tiberio; Modesti, Mauro. - In: ONCOLOGY REPORTS. - ISSN 1021-335X. - 6:1(1999), pp. 45-48.

99m Tc MIBI prone scintimammography in breast Paget's disease: A case report

MEZI, Silvia;SCOPINARO, Francesco;DAVID, vincenzo;MODESTI, Mauro
1999

Abstract

A 99m Tc MIBI prone scintimammography (PSM) was performed in a case of underlying Pager's disease of the breast. 99m Tc MIBI PSM showed a diffuse scintigraphic image like a spl ead of uptake fr om the deeply located zones of the breast toward epidermis. In vivo, 99m Tc MIBI PSM represents the spread of neoplastic Paget's cells probably due to attracs induced by chemotactic factors released by keratinocytes. This spread in Paget's disease is correlated to neu oncogene overexpression which increases the metastatic activity as a consequence of motility enhancement and growth stimulation effect. These scintigraphic images suggest that 99m Te MIBI PSM could be relevant in management of Paget's disease of the breast.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/253713
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