Here, we confirmed that a single oral dose of LND (100 mg/kg b.w.) to sexually mature Sprague-Dawley rats causes shrinkage and weight reduction of the testes after 48 h. These macroscopic changes correlated with histologic alterations revealed by light microscopy, consistent with partially reversible inhibition of spermatogenesis.

Effects of lonidamine on testicular and epididymal proteins in the rat / Leone, Mg; Grippa, E.; Guidolin, D.; Tita, Beatrice; ABDEL HAQ, H.; Gatto, M. T.; Bordi, F.; Cheng, Cy; Silvestrini, Bruno; Saso, Luciano. - In: REPRODUCTIVE TOXICOLOGY. - ISSN 0890-6238. - STAMPA. - 14(3):(2000), pp. 257-263. [10.1016/S0890-6238(00)]

Effects of lonidamine on testicular and epididymal proteins in the rat.

TITA, Beatrice;SILVESTRINI, Bruno;SASO, Luciano
2000

Abstract

Here, we confirmed that a single oral dose of LND (100 mg/kg b.w.) to sexually mature Sprague-Dawley rats causes shrinkage and weight reduction of the testes after 48 h. These macroscopic changes correlated with histologic alterations revealed by light microscopy, consistent with partially reversible inhibition of spermatogenesis.
2000
lonidamine; antispermatogenic drugs; testicular and epididymal proteins; alpha(1)-inhibitor-3; alpha(2)-macroglobulin; alpha(1)-macroglobulin; concanavalin A; SDS-PAGE
01 Pubblicazione su rivista::01a Articolo in rivista
Effects of lonidamine on testicular and epididymal proteins in the rat / Leone, Mg; Grippa, E.; Guidolin, D.; Tita, Beatrice; ABDEL HAQ, H.; Gatto, M. T.; Bordi, F.; Cheng, Cy; Silvestrini, Bruno; Saso, Luciano. - In: REPRODUCTIVE TOXICOLOGY. - ISSN 0890-6238. - STAMPA. - 14(3):(2000), pp. 257-263. [10.1016/S0890-6238(00)]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/253319
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