The present research is focused on the development of in vitro experimental models to prevent catheter-related infections. The approach is based on the adsorption of selected antibiotic molecules onto polyurethanes, the most frequently employed polymers in intravascular catheter manufacturing. Two functionalized polymers were tested displaying acidic or basic groups, respectively. The establishment of ion interactions resulted to be the better condition for antibiotic adsorption. As the antibiotic release is concerned, cefamandole nafate and vancomycin exhibited the strong drug-polymer interaction both showing a release value of about 15% in 48 hrs of washings vs. release values of about 30 and 40 % for rifampin and amoxicillin, respectively. As the antibacterial activity is concerned, the best results were obtained with cefamandole and rifampin adsorbed on the basic polymer.
Adsorption of antibiotics on functionalized polyurethanes as a strategy to prevent intravascular catheter-associated infections / Francolini, Iolanda; DI ROSA, Roberta; Piozzi, Antonella; Marconi, Valter; G., Donelli. - In: CLINICAL MICROBIOLOGY AND INFECTION. - ISSN 1198-743X. - STAMPA. - 9(S1):(2003), pp. 78-78. (Intervento presentato al convegno 13th European Congress of Clinical Microbiology and Infectious Diseaseas tenutosi a Glasgow, UK nel May 10-13) [10.1046/j.1469-0691.9.s1.83.x].
Adsorption of antibiotics on functionalized polyurethanes as a strategy to prevent intravascular catheter-associated infections.
FRANCOLINI, IOLANDA;DI ROSA, Roberta;PIOZZI, Antonella;MARCONI, Valter;
2003
Abstract
The present research is focused on the development of in vitro experimental models to prevent catheter-related infections. The approach is based on the adsorption of selected antibiotic molecules onto polyurethanes, the most frequently employed polymers in intravascular catheter manufacturing. Two functionalized polymers were tested displaying acidic or basic groups, respectively. The establishment of ion interactions resulted to be the better condition for antibiotic adsorption. As the antibiotic release is concerned, cefamandole nafate and vancomycin exhibited the strong drug-polymer interaction both showing a release value of about 15% in 48 hrs of washings vs. release values of about 30 and 40 % for rifampin and amoxicillin, respectively. As the antibacterial activity is concerned, the best results were obtained with cefamandole and rifampin adsorbed on the basic polymer.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
