The aim of the study was to evaluate whether the imbalance between IL-12 and IL-13 serum levels, reflecting Th1/Th2 activity, is related to class-specific circulating rheumatoid factors (RF) and anticardiolipin (aCL) antibodies in SLE. Using ELISA we measured serum IL-12, IL-13, RF and aCL antibodies in 73 SLE patients and 20 healthy controls. The determination of IL-12/IL-13 ratio showed that IL-12 levels were above (group A), equal to (group B) or below (group C) IL-13 levels in 71.2%, 15.1% and 13.7% of SLE patients, respectively. IgM-RF levels were significantly higher in group C than in groups A (P < 0.002) and B (P < 0.019). Group C had also higher IgM-aCL levels than group A (P < 0.04). No relationship between IL-12/IL-13 ratio and clinical or other laboratory parameters was found. It was concluded that the increased levels of both IgM-RF and IgM-aCL in patients with prevalent Th2 activity suggest that the predominance of Th2 over Th1 could drive autoantibody production in SLE patients.

Relationship of Interleukin-12 and Interleukin-13 imbalance with class-specific rheumatoid factors and anticardiolipin antibodies in systemic lupus erythematosus / Spadaro, Antonio; Scrivo, Rossana; M., Bombardieri; Riccieri, Valeria; T., Rinaldi; E., Taccari; Valesini, Guido. - In: CLINICAL RHEUMATOLOGY. - ISSN 0770-3198. - STAMPA. - 22:2(2003), pp. 107-111. [10.1007/s10067-002-0685-y]

Relationship of Interleukin-12 and Interleukin-13 imbalance with class-specific rheumatoid factors and anticardiolipin antibodies in systemic lupus erythematosus

SPADARO, Antonio;SCRIVO, Rossana;RICCIERI, Valeria;VALESINI, Guido
2003

Abstract

The aim of the study was to evaluate whether the imbalance between IL-12 and IL-13 serum levels, reflecting Th1/Th2 activity, is related to class-specific circulating rheumatoid factors (RF) and anticardiolipin (aCL) antibodies in SLE. Using ELISA we measured serum IL-12, IL-13, RF and aCL antibodies in 73 SLE patients and 20 healthy controls. The determination of IL-12/IL-13 ratio showed that IL-12 levels were above (group A), equal to (group B) or below (group C) IL-13 levels in 71.2%, 15.1% and 13.7% of SLE patients, respectively. IgM-RF levels were significantly higher in group C than in groups A (P < 0.002) and B (P < 0.019). Group C had also higher IgM-aCL levels than group A (P < 0.04). No relationship between IL-12/IL-13 ratio and clinical or other laboratory parameters was found. It was concluded that the increased levels of both IgM-RF and IgM-aCL in patients with prevalent Th2 activity suggest that the predominance of Th2 over Th1 could drive autoantibody production in SLE patients.
2003
il12/il13 ratio; igm anticardiolipin antibody; igm rheumatoid factor; sle
01 Pubblicazione su rivista::01a Articolo in rivista
Relationship of Interleukin-12 and Interleukin-13 imbalance with class-specific rheumatoid factors and anticardiolipin antibodies in systemic lupus erythematosus / Spadaro, Antonio; Scrivo, Rossana; M., Bombardieri; Riccieri, Valeria; T., Rinaldi; E., Taccari; Valesini, Guido. - In: CLINICAL RHEUMATOLOGY. - ISSN 0770-3198. - STAMPA. - 22:2(2003), pp. 107-111. [10.1007/s10067-002-0685-y]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/252014
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