It has long been known that the testis is an immunologically privileged site in the body, and that human seminal plasma possesses a generalized immunosuppressive activity. Multiple factors participate in the establishment of immunotolerance in the testis: the blood-tubular barrier; the local production of immunosuppressive molecules by Sertoli cells; and the Fas system as regulator of immunological homeostasis in both physiological and pathological conditions. Cytokine-induced up-regulation of Fas as well as of integrin ligands, which are known to be specific binding molecules for lymphocytes on the Sertoli cell surface, indicates that the 'nursing' cells of seminiferous epithelium might be important in the impairment of immune privilege, causing autoimmune orchitis. In addition, the soluble form of Fas-ligand protein present in the seminal plasma of infertile patients might suggest a role for this immunomodulatory protein in male infertility. Finally, an understanding of the mechanisms underlying immune privilege in the testis and in semen might help to clarify how cells expressing 'non-self' antigens (such as male gametes) can escape the immune system in both the male and female genital tracts.

Immunology and immupathology of male genital tract. Control and impairment of immune privilege in the testis and in semen / Filippini, A.; Riccioli, A.; Padula, F.; Lauretti, P.; D'Alessio, A.; DE CESARIS, P.; Gandini, Loredana; Lenzi, Andrea; Ziparo, Elio. - In: HUMAN REPRODUCTION UPDATE. - ISSN 1355-4786. - 7:(2001), pp. 444-449. [10.1093/humupd/7.5.444]

Immunology and immupathology of male genital tract. Control and impairment of immune privilege in the testis and in semen

FILIPPINI A.;RICCIOLI A.;GANDINI, Loredana;LENZI, Andrea;ZIPARO, Elio
2001

Abstract

It has long been known that the testis is an immunologically privileged site in the body, and that human seminal plasma possesses a generalized immunosuppressive activity. Multiple factors participate in the establishment of immunotolerance in the testis: the blood-tubular barrier; the local production of immunosuppressive molecules by Sertoli cells; and the Fas system as regulator of immunological homeostasis in both physiological and pathological conditions. Cytokine-induced up-regulation of Fas as well as of integrin ligands, which are known to be specific binding molecules for lymphocytes on the Sertoli cell surface, indicates that the 'nursing' cells of seminiferous epithelium might be important in the impairment of immune privilege, causing autoimmune orchitis. In addition, the soluble form of Fas-ligand protein present in the seminal plasma of infertile patients might suggest a role for this immunomodulatory protein in male infertility. Finally, an understanding of the mechanisms underlying immune privilege in the testis and in semen might help to clarify how cells expressing 'non-self' antigens (such as male gametes) can escape the immune system in both the male and female genital tracts.
2001
01 Pubblicazione su rivista::01a Articolo in rivista
Immunology and immupathology of male genital tract. Control and impairment of immune privilege in the testis and in semen / Filippini, A.; Riccioli, A.; Padula, F.; Lauretti, P.; D'Alessio, A.; DE CESARIS, P.; Gandini, Loredana; Lenzi, Andrea; Ziparo, Elio. - In: HUMAN REPRODUCTION UPDATE. - ISSN 1355-4786. - 7:(2001), pp. 444-449. [10.1093/humupd/7.5.444]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/251823
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 20
  • Scopus 92
  • ???jsp.display-item.citation.isi??? 69
social impact