The purpose of this work was to investigate the relation between BOLD signal sign and transient vessels volume variation induced by apnea. This stimulus consisting of breath holding after inspiration is able to induce a light slowing down in venous blood flow like in a sort of Valsalva maneuver. We observed diffuse negative BOLD responding areas at cortical level and a stronger negative response in correspondence of the main sinuses. These phenomena seem to be unrelated to a specific neural activity, appearing to be expressions of a mechanical variation in the hemodynamics. Our study suggests that particular care must be considered in the interpretation of fMRI findings, especially when patients with vascular-related cerebral diseases are involved. © 2003 Elsevier Inc. All rights reserved.
BOLD signal sign and transient vessels volume variation / G., Garreffa; Colonnese, Claudio; Macri', MARIA ANTONIETTA; Ma, ; N., Modugno; R., Rocca; Calistri, Valentina; E., De Cesare; E., Venditti; Maraviglia, Bruno. - In: MAGNETIC RESONANCE IMAGING. - ISSN 0730-725X. - 21:10(2003), pp. 1207-1212. (Intervento presentato al convegno International School on Magnetic Resonance and Brain Function tenutosi a ERICE, ITALY nel APR 06-10, 2003) [10.1016/j.mri.2003.08.022].
BOLD signal sign and transient vessels volume variation
COLONNESE, Claudio;MACRI', MARIA ANTONIETTA;CALISTRI, VALENTINA;MARAVIGLIA, Bruno
2003
Abstract
The purpose of this work was to investigate the relation between BOLD signal sign and transient vessels volume variation induced by apnea. This stimulus consisting of breath holding after inspiration is able to induce a light slowing down in venous blood flow like in a sort of Valsalva maneuver. We observed diffuse negative BOLD responding areas at cortical level and a stronger negative response in correspondence of the main sinuses. These phenomena seem to be unrelated to a specific neural activity, appearing to be expressions of a mechanical variation in the hemodynamics. Our study suggests that particular care must be considered in the interpretation of fMRI findings, especially when patients with vascular-related cerebral diseases are involved. © 2003 Elsevier Inc. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
