In the present study, we investigated the role of vasopressin in the development of quinpirole-induced hyperdipsia in the rat. We report that: (1), an acute intraperitoneal (i.p.) injection of 0.56 mg/kg of quinpirole increased plasma vasopressin (radioimmunoassay) at 15 min but not at 30 or 120 min; (2), nine daily injections of quinpirole (0.56 mg/kg, i.p.) progressively increased water intake and diuresis for a period of several hours after each treatment; (3), quinpirole hyperdipsia was associated with apparently normal levels of vasopressin (which might be considered inappropriately high in the presence of excessive drinking); (4), quinpirole reduced vasopressin and oxytocin, but not angiotensin, immunoreactivity in the supraoptic nucleus. These findings suggest that quinpirole hyperdipsia is a sound animal model of psychotic polydipsia. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

Dissociation in the effects of the D2/D3 dopaminergic agonist quinpirole on drinking and on vasopressin levels in the rat / Badiani, Aldo; Vaccaro, Rosa; Rosetta, Burdino; Casini, Arianna; Valeri, Pacifico; Renda, Tindaro Giuseppe; Nencini, Paolo. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - STAMPA. - 325:2(2002), pp. 79-82. [10.1016/s0304-3940(02)00261-6]

Dissociation in the effects of the D2/D3 dopaminergic agonist quinpirole on drinking and on vasopressin levels in the rat

BADIANI, Aldo;VACCARO, Rosa;CASINI, Arianna;VALERI, Pacifico;RENDA, Tindaro Giuseppe;NENCINI, Paolo
2002

Abstract

In the present study, we investigated the role of vasopressin in the development of quinpirole-induced hyperdipsia in the rat. We report that: (1), an acute intraperitoneal (i.p.) injection of 0.56 mg/kg of quinpirole increased plasma vasopressin (radioimmunoassay) at 15 min but not at 30 or 120 min; (2), nine daily injections of quinpirole (0.56 mg/kg, i.p.) progressively increased water intake and diuresis for a period of several hours after each treatment; (3), quinpirole hyperdipsia was associated with apparently normal levels of vasopressin (which might be considered inappropriately high in the presence of excessive drinking); (4), quinpirole reduced vasopressin and oxytocin, but not angiotensin, immunoreactivity in the supraoptic nucleus. These findings suggest that quinpirole hyperdipsia is a sound animal model of psychotic polydipsia. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
angiotensin; antidiuretic hormone; diuresis; hyperdipsia; oxytocin; polydipsia; sensitization; supraoptic nucleus; syndrome of inappropriate secretion of antidiuretic hormone; water intake
01 Pubblicazione su rivista::01a Articolo in rivista
Dissociation in the effects of the D2/D3 dopaminergic agonist quinpirole on drinking and on vasopressin levels in the rat / Badiani, Aldo; Vaccaro, Rosa; Rosetta, Burdino; Casini, Arianna; Valeri, Pacifico; Renda, Tindaro Giuseppe; Nencini, Paolo. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - STAMPA. - 325:2(2002), pp. 79-82. [10.1016/s0304-3940(02)00261-6]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/250979
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