IMMUNOSUPPRESSIVE drugs that are currently in use effectively inhibit the T-lymphocyte–dependent immune response. The introduction of cyclosporine (CyA) in the early 1980s marked a major improvement in the shortterm results following renal transplantation. By the end of that decade a new IL-2 (interleukin-2) inhibitor, tacrolimus, became available in the clinic. Twenty years have passed since the introduction of the first of these types of drugs, and the down-regulation of IL-2 via calcineurin inhibition continues to be the cornerstone of immunosuppressive therapy following solid-organ transplantation. Other immunosuppressive drugs, including those that have become available recently, such as mycophenolate mofetil (MMF), sirolimus, and others, play an important role, not as cornerstone regimens, but as adjunctive therapies.
Tacrolimus as cornerstone immunosuppressant in kidney transplantation / Berloco, Pasquale Bartolomeo; Rossi, Massimo; Pretagostini, Renzo; N., Sociu Foca Cortesini; Cortesini, Raffaello. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - STAMPA. - 33:1-2(2001), pp. 994-996. (Intervento presentato al convegno 18th World Congress of the Transplantation-Society tenutosi a ROME, ITALY nel AUG 27-SEP 01, 2000) [10.1016/s0041-1345(00)02301-0].
Tacrolimus as cornerstone immunosuppressant in kidney transplantation
BERLOCO, Pasquale Bartolomeo;ROSSI, MASSIMO;PRETAGOSTINI, Renzo;CORTESINI, Raffaello
2001
Abstract
IMMUNOSUPPRESSIVE drugs that are currently in use effectively inhibit the T-lymphocyte–dependent immune response. The introduction of cyclosporine (CyA) in the early 1980s marked a major improvement in the shortterm results following renal transplantation. By the end of that decade a new IL-2 (interleukin-2) inhibitor, tacrolimus, became available in the clinic. Twenty years have passed since the introduction of the first of these types of drugs, and the down-regulation of IL-2 via calcineurin inhibition continues to be the cornerstone of immunosuppressive therapy following solid-organ transplantation. Other immunosuppressive drugs, including those that have become available recently, such as mycophenolate mofetil (MMF), sirolimus, and others, play an important role, not as cornerstone regimens, but as adjunctive therapies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
