In the model of trimethyltin (TMT)-induced neurodegeneration in developing rat hippocampus, calretinin (CR)-immunoreactive neurons are selectively spared and even more numerous than in controls. We investigated the possibility of an additional synthesis of CR using RT-PCR. The amount of CR mRNA increased significantly after TMT treatment. CR mRNA production after TMT treatment could hypothetically be regarded as a compensatory phenomenon in developing rats. (C) 2002 Elsevier Science B.V. All rights reserved.
De novo expression of calretinin in trimethyltin-induced degeneration of developing rat hippocampus / Businaro, Rita; Valentina, Corvino; Maria Concetta, Geloso; DE SANTIS, Elena; Fumagalli, Lorenzo; Fabrizio, Michetti. - In: MOLECULAR BRAIN RESEARCH. - ISSN 0169-328X. - 98:1-2(2002), pp. 141-144. [10.1016/s0169-328x(01)00334-5]