Immunohistochemistry was used to map the induction of c-Fos protein in the forebrain of rats treated with heroin. Acute injection of heroin to drug-naive rats caused significant induction of c-Fos protein in the nucleus accumbens shell. whereas the sa-me dose of heroin given to drug-sensitized rats significantly increased c-Fos immunoreactivity in the dorsomedial caudate-putamen. These results show that the heroin-induced pattern of c-Fos protein in the rat striatum differs according to the rat's drug history. These findings may represent a neural correlate of the motor components of heroin sensitization. (C) 2002 Elsevier Science B.V. All rights reserved.
Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum / D'Este, Loredana; Scontrini, Alessandra; Casini, Arianna; Pontieri, FRANCESCO ERNESTO; Renda, Tindaro Giuseppe. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 933:2(2002), pp. 144-149. [10.1016/s0006-8993(02)02312-0]
Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum
D'ESTE, Loredana;SCONTRINI, ALESSANDRA;CASINI, Arianna;PONTIERI, FRANCESCO ERNESTO;RENDA, Tindaro Giuseppe
2002
Abstract
Immunohistochemistry was used to map the induction of c-Fos protein in the forebrain of rats treated with heroin. Acute injection of heroin to drug-naive rats caused significant induction of c-Fos protein in the nucleus accumbens shell. whereas the sa-me dose of heroin given to drug-sensitized rats significantly increased c-Fos immunoreactivity in the dorsomedial caudate-putamen. These results show that the heroin-induced pattern of c-Fos protein in the rat striatum differs according to the rat's drug history. These findings may represent a neural correlate of the motor components of heroin sensitization. (C) 2002 Elsevier Science B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
