Different members of the Notch family have been described to play a critical role in T cell lineage commitment and T cell development and functions. Nevertheless, whether they act as redundant molecules, by affecting the same molecular mechanisms, or play distinct roles in T cell differentiation and/or functions is not clear. Altered Notch3 signaling impairs the developmentally regulated interplay between pre-TCR and NF-kappaB signaling and allows the disruption of early thymocyte differentiation and the development of T cell leukemia, thus identifying the crucial role of Notch3 receptor in the coordination of T cell differentiation and growth control. (C) 2003 Elsevier Science Ltd. All rights reserved.

Notch3, another Notch in T cell development / Bellavia, Diana; Campese, Antonio Francesco; Vacca, Alessandra; Gulino, Alberto; Screpanti, Isabella. - In: SEMINARS IN IMMUNOLOGY. - ISSN 1044-5323. - STAMPA. - 15:2(2003), pp. 107-112. [10.1016/s1044-5323(03)00007-1]

Notch3, another Notch in T cell development

BELLAVIA, Diana;CAMPESE, Antonio Francesco;VACCA, Alessandra;GULINO, Alberto;SCREPANTI, Isabella
2003

Abstract

Different members of the Notch family have been described to play a critical role in T cell lineage commitment and T cell development and functions. Nevertheless, whether they act as redundant molecules, by affecting the same molecular mechanisms, or play distinct roles in T cell differentiation and/or functions is not clear. Altered Notch3 signaling impairs the developmentally regulated interplay between pre-TCR and NF-kappaB signaling and allows the disruption of early thymocyte differentiation and the development of T cell leukemia, thus identifying the crucial role of Notch3 receptor in the coordination of T cell differentiation and growth control. (C) 2003 Elsevier Science Ltd. All rights reserved.
2003
e2a; nf-kappa b; nf-κb; notch3; pre-tcr; thymus
01 Pubblicazione su rivista::01a Articolo in rivista
Notch3, another Notch in T cell development / Bellavia, Diana; Campese, Antonio Francesco; Vacca, Alessandra; Gulino, Alberto; Screpanti, Isabella. - In: SEMINARS IN IMMUNOLOGY. - ISSN 1044-5323. - STAMPA. - 15:2(2003), pp. 107-112. [10.1016/s1044-5323(03)00007-1]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/250522
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