Different members of the Notch family have been described to play a critical role in T cell lineage commitment and T cell development and functions. Nevertheless, whether they act as redundant molecules, by affecting the same molecular mechanisms, or play distinct roles in T cell differentiation and/or functions is not clear. Altered Notch3 signaling impairs the developmentally regulated interplay between pre-TCR and NF-kappaB signaling and allows the disruption of early thymocyte differentiation and the development of T cell leukemia, thus identifying the crucial role of Notch3 receptor in the coordination of T cell differentiation and growth control. (C) 2003 Elsevier Science Ltd. All rights reserved.
Notch3, another Notch in T cell development / Bellavia, Diana; Campese, Antonio Francesco; Vacca, Alessandra; Gulino, Alberto; Screpanti, Isabella. - In: SEMINARS IN IMMUNOLOGY. - ISSN 1044-5323. - STAMPA. - 15:2(2003), pp. 107-112. [10.1016/s1044-5323(03)00007-1]
Notch3, another Notch in T cell development
BELLAVIA, Diana;CAMPESE, Antonio Francesco;VACCA, Alessandra;GULINO, Alberto;SCREPANTI, Isabella
2003
Abstract
Different members of the Notch family have been described to play a critical role in T cell lineage commitment and T cell development and functions. Nevertheless, whether they act as redundant molecules, by affecting the same molecular mechanisms, or play distinct roles in T cell differentiation and/or functions is not clear. Altered Notch3 signaling impairs the developmentally regulated interplay between pre-TCR and NF-kappaB signaling and allows the disruption of early thymocyte differentiation and the development of T cell leukemia, thus identifying the crucial role of Notch3 receptor in the coordination of T cell differentiation and growth control. (C) 2003 Elsevier Science Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
