ALTHOUGH THE mechanism of organ allograft rejection has been extensively studied, little is currently known about the regulatory T cells that can maintain the state of quiescence. Recent evidence indicates that T suppressor cells (Ts) can be generated in vitro by multiple allostimulation of CD81CD282 T cells with allogeneic APC. Ts were shown to recognize HLA class I alloantigens on target APC and inhibit their ability to provide costimulatory signals to Th, blocking transcription of CD80, CD86, and CD40 molecules. We have explored the possibility that allospecific CD81CD282 Ts down-regulate the immune response against the graft.1–7
ORGAN ALLOGRAFT RECIPIENTS DEVELOP HLA CLASS I-SPECIFIC T SUPPRESSOR CELLS / Bruzzone, Paolo; E., Renna Molajoni; Cinti, Paola; Evangelista, Berta; D., Peritore; Poli, Luca; Pretagostini, Renzo; Berloco, Pasquale Bartolomeo; Cortesini, Raffaello; N., Cortesini Suciu Foca. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - STAMPA. - 33:1-2(2001), pp. 78-79. [10.1016/S0041-1345(00)01911-4]
ORGAN ALLOGRAFT RECIPIENTS DEVELOP HLA CLASS I-SPECIFIC T SUPPRESSOR CELLS
BRUZZONE, Paolo;CINTI, Paola;EVANGELISTA, Berta;POLI, Luca;PRETAGOSTINI, Renzo;BERLOCO, Pasquale Bartolomeo;CORTESINI, Raffaello;
2001
Abstract
ALTHOUGH THE mechanism of organ allograft rejection has been extensively studied, little is currently known about the regulatory T cells that can maintain the state of quiescence. Recent evidence indicates that T suppressor cells (Ts) can be generated in vitro by multiple allostimulation of CD81CD282 T cells with allogeneic APC. Ts were shown to recognize HLA class I alloantigens on target APC and inhibit their ability to provide costimulatory signals to Th, blocking transcription of CD80, CD86, and CD40 molecules. We have explored the possibility that allospecific CD81CD282 Ts down-regulate the immune response against the graft.1–7I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
