The distribution of inter-alpha-trypsin inhibitor (ITI) and related inhibitors was investigated in normal human tissues and body fluids by using an enzyme-linked immunosorbent assay (ELISA) and a streptavidin-biotin-peroxidase immunohistochemical technique. ITI-related immunoreactivity was localized in different cell types of various organs, such as liver, kidney, testis, gross intestine, cutis and brain. Specific immunoreactivity was also detected in serum, urine and bronchial mucus. This widespread, but not ubiquitous pattern of localization suggests that, in addition to the well known plasmatic role, ITI and/or ITI-related inhibitors may play a number of different physiological roles in various human tissues.
Inter-alpha-trypsin inhibitor-related immunoreactivity in human tissues and body fluids / Businaro, Rita; TRANQUILLI LEALI, Francesca Maria; G., Derenzis; Pompili, Elena; G., Pagliari; G., Menghi; Fumagalli, Lorenzo. - In: CELLULAR AND MOLECULAR BIOLOGY. - ISSN 0145-5680. - 38:4(1992), pp. 463-471.
Inter-alpha-trypsin inhibitor-related immunoreactivity in human tissues and body fluids.
BUSINARO, Rita;TRANQUILLI LEALI, Francesca Maria;POMPILI, Elena;FUMAGALLI, Lorenzo
1992
Abstract
The distribution of inter-alpha-trypsin inhibitor (ITI) and related inhibitors was investigated in normal human tissues and body fluids by using an enzyme-linked immunosorbent assay (ELISA) and a streptavidin-biotin-peroxidase immunohistochemical technique. ITI-related immunoreactivity was localized in different cell types of various organs, such as liver, kidney, testis, gross intestine, cutis and brain. Specific immunoreactivity was also detected in serum, urine and bronchial mucus. This widespread, but not ubiquitous pattern of localization suggests that, in addition to the well known plasmatic role, ITI and/or ITI-related inhibitors may play a number of different physiological roles in various human tissues.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
