Doppler sonography measurement of portal flow velocity (PFV) after glucagon injection was performed in 35 patients with chronic hepatitis C virus (HCV) infection. Patients were divided into three groups: group 1 = no or mild liver fibrosis; group 2 = moderate to severe liver fibrosis, and group 3 = liver cirrhosis, All patients were examined using a Doppler ultrasound (US) multipurpose equipment and a convex 3.5-MHz probe, 10 min before (baseline), as well as 5 and 10 min after, IV administration of 1 mg of glucagon chloride. No significant differences were found in mean baseline PFV among group 1 (19.4 +/- 2.4 cm/s), group 2 (20.1 +/- 3.6 cm/s) and group 3 (17.5 +/- 3.7 cm/s), Five minutes after glucagon injection, all three groups showed significantly increased values of mean PFV (25.6 +/- 4.8, 23.7 +/- 4.0 and 19.5 +/- 5.0 cm/s, respectively; p < 0.05 vs. baseline). The mean increase of PFV above baseline was significantly higher in group 1 (7.9 +/- 3.7 cm/s) than in group 2 (4.5 +/- 3,9 cm/s) (p < 0.05) or in group 3 (2.7 +/- 2.3 cm/s) (p < 0.05), A significant inverse correlation was found between individual values of fibrosis score and of individual increase of PFV, m patients with chronic HCV infection, Doppler sonography measurement of PFV after glucagon injection could be useful in assessing the severity of liver histological damage. (E-mail: fabrizio.toccaceli@uniromal.it) (C) 2001 World Federation for Ultrasound in Medicine & Biology.

Doppler sonography measurement of portal blood flow velocity after glucagon injection in patients with chronic HCV infection / Silvia, Sereno; Toccaceli, Fabrizio; Vincenzo, Russo; Fabio, Iacomi; Enrico Maria, Zardi; Laghi, Vittorio. - In: ULTRASOUND IN MEDICINE AND BIOLOGY. - ISSN 0301-5629. - 27:5(2001), pp. 723-726. [10.1016/s0301-5629(01)00347-7]

Doppler sonography measurement of portal blood flow velocity after glucagon injection in patients with chronic HCV infection

TOCCACELI, Fabrizio;LAGHI, Vittorio
2001

Abstract

Doppler sonography measurement of portal flow velocity (PFV) after glucagon injection was performed in 35 patients with chronic hepatitis C virus (HCV) infection. Patients were divided into three groups: group 1 = no or mild liver fibrosis; group 2 = moderate to severe liver fibrosis, and group 3 = liver cirrhosis, All patients were examined using a Doppler ultrasound (US) multipurpose equipment and a convex 3.5-MHz probe, 10 min before (baseline), as well as 5 and 10 min after, IV administration of 1 mg of glucagon chloride. No significant differences were found in mean baseline PFV among group 1 (19.4 +/- 2.4 cm/s), group 2 (20.1 +/- 3.6 cm/s) and group 3 (17.5 +/- 3.7 cm/s), Five minutes after glucagon injection, all three groups showed significantly increased values of mean PFV (25.6 +/- 4.8, 23.7 +/- 4.0 and 19.5 +/- 5.0 cm/s, respectively; p < 0.05 vs. baseline). The mean increase of PFV above baseline was significantly higher in group 1 (7.9 +/- 3.7 cm/s) than in group 2 (4.5 +/- 3,9 cm/s) (p < 0.05) or in group 3 (2.7 +/- 2.3 cm/s) (p < 0.05), A significant inverse correlation was found between individual values of fibrosis score and of individual increase of PFV, m patients with chronic HCV infection, Doppler sonography measurement of PFV after glucagon injection could be useful in assessing the severity of liver histological damage. (E-mail: fabrizio.toccaceli@uniromal.it) (C) 2001 World Federation for Ultrasound in Medicine & Biology.
2001
doppler sonography; glucagon; hcv infection; portal flow velocity
01 Pubblicazione su rivista::01a Articolo in rivista
Doppler sonography measurement of portal blood flow velocity after glucagon injection in patients with chronic HCV infection / Silvia, Sereno; Toccaceli, Fabrizio; Vincenzo, Russo; Fabio, Iacomi; Enrico Maria, Zardi; Laghi, Vittorio. - In: ULTRASOUND IN MEDICINE AND BIOLOGY. - ISSN 0301-5629. - 27:5(2001), pp. 723-726. [10.1016/s0301-5629(01)00347-7]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/249935
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