KIDNEY transplantation from a living donor has always been considered a valid source to increase the donor pool. In the last decade excellent results have also been achieved with LURD (living unrelated donor) transplantation. The aim of this study was to evaluate the impact of immunological factors such as HLA compatibility, pregnancies, pretransplant blood transfusions and “taboo mismatch” (MM) on short- and long-term graft survival. The introduction of cyclosporine (CyA) minimized the influence of HLA compatibility on graft survival in living donor renal transplantation, allowing the achievement of good results even in poor compatibility patients, such as LURD recipients. In our experience other immunological factors, pregnancies, and pretransplant blood transfusion seem not to influence graft survival. Taboo MM alone do not negatively influence LRD (living related donor) group, whereas a negative influence is present in the LURD
Effect of HLA compatibility, pregnancies, blood transfusions, and taboo mismatches in living unrelated kidney transplantation / Poli, Luca; Pretagostini, Renzo; Rossi, Massimo; Novelli, Gilnardo; Berloco, Pasquale Bartolomeo; Iappelli, Massimo; Casciaro, Giovanni Enrico; V., De Blasis; M., Colonnello; C., Cancrini; D., Peritore; R., Cortesini. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - STAMPA. - 33:1-2(2001), pp. 1136-1138. (Intervento presentato al convegno 18th World Congress of the Transplantation-Society tenutosi a ROME, ITALY nel AUG 27-SEP 01, 2000) [10.1016/s0041-1345(00)02805-0].
Effect of HLA compatibility, pregnancies, blood transfusions, and taboo mismatches in living unrelated kidney transplantation
POLI, Luca;PRETAGOSTINI, Renzo;ROSSI, MASSIMO;NOVELLI, Gilnardo;BERLOCO, Pasquale Bartolomeo;IAPPELLI, Massimo;CASCIARO, Giovanni Enrico;
2001
Abstract
KIDNEY transplantation from a living donor has always been considered a valid source to increase the donor pool. In the last decade excellent results have also been achieved with LURD (living unrelated donor) transplantation. The aim of this study was to evaluate the impact of immunological factors such as HLA compatibility, pregnancies, pretransplant blood transfusions and “taboo mismatch” (MM) on short- and long-term graft survival. The introduction of cyclosporine (CyA) minimized the influence of HLA compatibility on graft survival in living donor renal transplantation, allowing the achievement of good results even in poor compatibility patients, such as LURD recipients. In our experience other immunological factors, pregnancies, and pretransplant blood transfusion seem not to influence graft survival. Taboo MM alone do not negatively influence LRD (living related donor) group, whereas a negative influence is present in the LURDI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
