Thirty-one patients with advanced colorectal cancer were treated with a regimen of epirubicin, cisplatin and continuous-infusion (c.i.) 5-fluorouracil (5-FU) (ECF regimen). Twenty-seven patients were evaluable for response rate (RR), progression-free survival (PFS) and overall survival (OS). In this study, the ECF chemotherapy yielded a 51% RR with a PFS of more than 8 months, an OS of more than 11 months and tolerable toxicity. In spite of the perplexity concerning the use of anthracyclines in colorectal cancer, the ECF regimen seems to be a possible treatment even for this malignancy. Controlled studies with ECF versus standard treatments and versus 5-FU alone in c.i. are necessary.
Epirubicin, Cisplatin and continuous infusion 5-Fluorouracil (ECF regimen) in the treatment of advanced colorectal cancer / Gargano, L; Menichetti, Et; Marcellini, M; Seminara, Patrizia; Caporale, Alessandro; Konstantatoy, E; Masciangelo, Raffaele; Franchi, Fabrizio. - In: CHEMOTHERAPY. - ISSN 0009-3157. - 47:(2001), pp. 438-443. [10.1159/000048555]
Epirubicin, Cisplatin and continuous infusion 5-Fluorouracil (ECF regimen) in the treatment of advanced colorectal cancer
SEMINARA, Patrizia;CAPORALE, Alessandro;MASCIANGELO, Raffaele;FRANCHI, Fabrizio
2001
Abstract
Thirty-one patients with advanced colorectal cancer were treated with a regimen of epirubicin, cisplatin and continuous-infusion (c.i.) 5-fluorouracil (5-FU) (ECF regimen). Twenty-seven patients were evaluable for response rate (RR), progression-free survival (PFS) and overall survival (OS). In this study, the ECF chemotherapy yielded a 51% RR with a PFS of more than 8 months, an OS of more than 11 months and tolerable toxicity. In spite of the perplexity concerning the use of anthracyclines in colorectal cancer, the ECF regimen seems to be a possible treatment even for this malignancy. Controlled studies with ECF versus standard treatments and versus 5-FU alone in c.i. are necessary.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.