Acetowhitening of the vulva has been related to a subclinical human papillomavirus (HPV) infection. No consense has been reached about undertaking -or not- any therapy for these acetowhite changes. We have observed from our clinical experience and in a 10 years observational follow-up, that acetowhitening of the vulva regarding high risk (16-18) and low risk (6-11) HPV groups (as assessed by PCR analysis) significantly decreased; and acetowhitening areas negative to polymerase chain reaction (PCR), significantly increased from 53% (202/382) to 85% (276/325) (P<0.001). Our findings suggest that independently from HPV type and in the absence of cofactors, there is a statistically significant spontaneous remission of these areas.
The prognostic significance of acetowhitening of the vulva and HPV-DNA test. A multicentre study / Frega, Antonio; Stentella, Patrizia; Anceschi, Maurizio Marco; J. J., Piazze; A., Tinari; Pachi', Antonio; E. V., Cosmi; M., Marchionni; C., Villani. - In: CANCER LETTERS. - ISSN 0304-3835. - 172:2(2001), pp. 133-135. [10.1016/s0304-3835(01)00643-7]
The prognostic significance of acetowhitening of the vulva and HPV-DNA test. A multicentre study
FREGA, Antonio;STENTELLA, Patrizia;ANCESCHI, Maurizio Marco;PACHI', Antonio;
2001
Abstract
Acetowhitening of the vulva has been related to a subclinical human papillomavirus (HPV) infection. No consense has been reached about undertaking -or not- any therapy for these acetowhite changes. We have observed from our clinical experience and in a 10 years observational follow-up, that acetowhitening of the vulva regarding high risk (16-18) and low risk (6-11) HPV groups (as assessed by PCR analysis) significantly decreased; and acetowhitening areas negative to polymerase chain reaction (PCR), significantly increased from 53% (202/382) to 85% (276/325) (P<0.001). Our findings suggest that independently from HPV type and in the absence of cofactors, there is a statistically significant spontaneous remission of these areas.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
