Gas-Phase Enantioselectivity

A review with >60 refs. Detn. of the intrinsic noncovalent interactions governing chiral recognition in diastereomeric complexes constitutes the basis for understanding information transfer between mols. in living systems as well as in synthetic supramol. structures. The most important exptl. methodologies used so far for this task are illustrated. Emphasis is put on the principles and applications of techniques such as radiolysis, Fourier-transform ion cyclotron resonance (FTICR) and collision-induced dissocn. (CID) mass spectrometry, and resonance-enhanced multiphoton ionization time-of-flight (REMPI-TOF) spectroscopy, that allow measurement of the relative stability of diastereomeric ion- and mol.-mol. complexes and quantification of the short-range forces controlling their enantioselective evolution to products.