We describe a novel macrocyclic minireceptor that is assembled from a chiral 1,2-diamine and 5-allyloxyisophthalic acid. After immobilization on HPLC silica, the chiral macrocycle preferentially binds the l-enantiomers of simple amino acid derivatives, with enantioselectivities values up to 3.0 kcal/mol.
A chiral A(2)B(2) macrocyclic minireceptor with extreme enantioselectivity / Gasparrini, Francesco; Misiti, Domenico; Pierini, Marco; Villani, Claudio. - In: ORGANIC LETTERS. - ISSN 1523-7060. - STAMPA. - 4:(2002), pp. 3993-3996. [10.1021/ol026363g]
A chiral A(2)B(2) macrocyclic minireceptor with extreme enantioselectivity
GASPARRINI, Francesco;MISITI, Domenico;PIERINI, MARCO;VILLANI, Claudio
2002
Abstract
We describe a novel macrocyclic minireceptor that is assembled from a chiral 1,2-diamine and 5-allyloxyisophthalic acid. After immobilization on HPLC silica, the chiral macrocycle preferentially binds the l-enantiomers of simple amino acid derivatives, with enantioselectivities values up to 3.0 kcal/mol.File allegati a questo prodotto
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