[GRAPHICS] 1,2-Dithiolanes present several points of interest for both peptide and medicinal chemistry, yet no chiral alpha-amino acids containing this five-membered heterocyclic system are available. We report here the first synthesis of N- and C-protected derivative of (S)-2-amino-3-(1,2-dithiolan4-yl)propionic acid (Adp) and its 1,3-dithiolic form.
Synthesis of 1,2-dithiolane analogues of leucine for potential use in peptide chemistry / Lucente, Gino; Morera, Enrico; Francesco, Pinnen. - In: ORGANIC LETTERS. - ISSN 1523-7060. - 4:7(2002), pp. 1139-1142. [10.1021/ol0255458]