The expression of both Notch3 and pre-T-cell-receptor (pre-TCR) invariant chain appears to be a common feature of all T-cell acute lymphoblastic leukemias (T-ALL). Notch genes, and other genes that are dysregulated in some T-ALL subgroups, encode factors that play a crucial role in both T-cell development and leukemogenesis. A complex network of signals, involving Notchs, pre-TCR, nuclear factor kappaB and E2A, appears to be responsible for the leukemogenesis process. Thus, T-ALL is a paradigm for developmental pathways that underlie the pathogenesis of this disease.

Notch, a unifying target in T-cell acute lymphoblastic leukemia? / Screpanti, Isabella; Bellavia, Diana; Campese, Antonio Francesco; Frati, Luigi; Gulino, Alberto. - In: TRENDS IN MOLECULAR MEDICINE. - ISSN 1471-4914. - STAMPA. - 9:1(2003), pp. 30-35. [10.1016/s1471-4914(02)00003-5]

Notch, a unifying target in T-cell acute lymphoblastic leukemia?

SCREPANTI, Isabella;BELLAVIA, Diana;CAMPESE, Antonio Francesco;FRATI, Luigi;GULINO, Alberto
2003

Abstract

The expression of both Notch3 and pre-T-cell-receptor (pre-TCR) invariant chain appears to be a common feature of all T-cell acute lymphoblastic leukemias (T-ALL). Notch genes, and other genes that are dysregulated in some T-ALL subgroups, encode factors that play a crucial role in both T-cell development and leukemogenesis. A complex network of signals, involving Notchs, pre-TCR, nuclear factor kappaB and E2A, appears to be responsible for the leukemogenesis process. Thus, T-ALL is a paradigm for developmental pathways that underlie the pathogenesis of this disease.
2003
activation; ankyrin repeat; differentiation; gene; leukemia/lymphoma; maturation; mice; neoplastic transformation; nf-kappa-b; signaling promotes
01 Pubblicazione su rivista::01a Articolo in rivista
Notch, a unifying target in T-cell acute lymphoblastic leukemia? / Screpanti, Isabella; Bellavia, Diana; Campese, Antonio Francesco; Frati, Luigi; Gulino, Alberto. - In: TRENDS IN MOLECULAR MEDICINE. - ISSN 1471-4914. - STAMPA. - 9:1(2003), pp. 30-35. [10.1016/s1471-4914(02)00003-5]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/248704
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