The expression of both Notch3 and pre-T-cell-receptor (pre-TCR) invariant chain appears to be a common feature of all T-cell acute lymphoblastic leukemias (T-ALL). Notch genes, and other genes that are dysregulated in some T-ALL subgroups, encode factors that play a crucial role in both T-cell development and leukemogenesis. A complex network of signals, involving Notchs, pre-TCR, nuclear factor kappaB and E2A, appears to be responsible for the leukemogenesis process. Thus, T-ALL is a paradigm for developmental pathways that underlie the pathogenesis of this disease.
Notch, a unifying target in T-cell acute lymphoblastic leukemia? / Screpanti, Isabella; Bellavia, Diana; Campese, Antonio Francesco; Frati, Luigi; Gulino, Alberto. - In: TRENDS IN MOLECULAR MEDICINE. - ISSN 1471-4914. - STAMPA. - 9:1(2003), pp. 30-35. [10.1016/s1471-4914(02)00003-5]
Notch, a unifying target in T-cell acute lymphoblastic leukemia?
SCREPANTI, Isabella;BELLAVIA, Diana;CAMPESE, Antonio Francesco;FRATI, Luigi;GULINO, Alberto
2003
Abstract
The expression of both Notch3 and pre-T-cell-receptor (pre-TCR) invariant chain appears to be a common feature of all T-cell acute lymphoblastic leukemias (T-ALL). Notch genes, and other genes that are dysregulated in some T-ALL subgroups, encode factors that play a crucial role in both T-cell development and leukemogenesis. A complex network of signals, involving Notchs, pre-TCR, nuclear factor kappaB and E2A, appears to be responsible for the leukemogenesis process. Thus, T-ALL is a paradigm for developmental pathways that underlie the pathogenesis of this disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
