ALTHOUGH the liver is known to be the organ allograft that is best tolerated, there are no objective immunological criteria which can guide clinical efforts to diminish or withdraw immunosuppression. In previous studies we have demonstrated that acute rejection of liver allografts is mediated to a large extent by recipient T cells that recognize MHC allopeptides via the indirect pathway.1 In the present study we investigated the role of allospecific T-suppressor cells2–7 in downregulating allopeptide reactivity and acute rejection in liver allograft recipients.
Allospecific T suppressor cells in liver transplantation / Molajoni, Er; Cinti, P; Ho, E; Evangelista, Berta; Lonardo, Mt; Rossi, Massimo; Iappelli, M; DELLA PIETRA, Fatima; Cortesini, R; SOCIU FOCA CORTESINI, N.. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - STAMPA. - 33:(2001), pp. 1381-1383. [10.1016/S0041-1345(00)02519-7]
Allospecific T suppressor cells in liver transplantation
EVANGELISTA, Berta;ROSSI, MASSIMO;DELLA PIETRA, Fatima;
2001
Abstract
ALTHOUGH the liver is known to be the organ allograft that is best tolerated, there are no objective immunological criteria which can guide clinical efforts to diminish or withdraw immunosuppression. In previous studies we have demonstrated that acute rejection of liver allografts is mediated to a large extent by recipient T cells that recognize MHC allopeptides via the indirect pathway.1 In the present study we investigated the role of allospecific T-suppressor cells2–7 in downregulating allopeptide reactivity and acute rejection in liver allograft recipients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
