The effect of oleanolic acid on the growth of human immunodeficiency virus-1 (HIV-1) in cultures of human peripheral mononuclear cells (PBMC) and of monocyte/macrophages (M/M) is described. The inhibitory activity was also evaluated on PBMC obtained from HIV-1 infected patients. Oleanolic acid inhibited the HIV-1 replication in all the cellular systems used. As regards the mechanism of action, oleanolic acid inhibited the HIV-1 protease activity in vitro
In vitro anti-HIV activity of oleanolic acid on infected human mononuclear cells / Lichtner, Miriam; Battinelli, L.; Marzi, M.; Mastroianni, Claudio Maria; Vullo, Vincenzo; Mengoni, Fabio; Mazzanti, Gabriela. - In: PLANTA MEDICA. - ISSN 0032-0943. - STAMPA. - 68:2(2002), pp. 111-114. [10.1055/s-2002-20256]
In vitro anti-HIV activity of oleanolic acid on infected human mononuclear cells
LICHTNER, Miriam;MASTROIANNI, Claudio Maria;VULLO, Vincenzo;MENGONI, Fabio;MAZZANTI, Gabriela
2002
Abstract
The effect of oleanolic acid on the growth of human immunodeficiency virus-1 (HIV-1) in cultures of human peripheral mononuclear cells (PBMC) and of monocyte/macrophages (M/M) is described. The inhibitory activity was also evaluated on PBMC obtained from HIV-1 infected patients. Oleanolic acid inhibited the HIV-1 replication in all the cellular systems used. As regards the mechanism of action, oleanolic acid inhibited the HIV-1 protease activity in vitroI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
