Malignant mesothelioma (MM) is predominantly a sporadic malignancy linked to exposure to asbestos. Clustering of MM in families suggests genetic susceptibility as a contributing factor. We performed comparative genomic hybridization (CGH) analysis on tumor samples from members of a family with MM of the pleura and a history of parental cancer. Our specific aim was to find a recurrent copy number loss indicating the chromosomal area to which a gene underlying the development of MM could be assigned according to the Knudson two-hit hypothesis. We found losses at 1p, 6q. 9p. 13q, and 14q. The copy number changes were very similar to those reported in sporadic cases. Our findings and results from sporadic cases highlight the importance of cloning the genes in the loss sites at 1p, 6q, 14q, and 22q. (C) 2001 Elsevier Science Inc. All rights reserved.
DNA copy number changes in familial malignant mesothelioma / Ascoli, Valeria; Yan, Aalto; Caterina Carnovale, Scalzo; Nardi, Francesco; Daniela, Falzetti; Cristina, Mecucci; Sakari, Knuutila. - In: CANCER GENETICS AND CYTOGENETICS. - ISSN 0165-4608. - 127:1(2001), pp. 80-82. [10.1016/s0165-4608(00)00420-9]
DNA copy number changes in familial malignant mesothelioma
ASCOLI, Valeria;NARDI, Francesco;
2001
Abstract
Malignant mesothelioma (MM) is predominantly a sporadic malignancy linked to exposure to asbestos. Clustering of MM in families suggests genetic susceptibility as a contributing factor. We performed comparative genomic hybridization (CGH) analysis on tumor samples from members of a family with MM of the pleura and a history of parental cancer. Our specific aim was to find a recurrent copy number loss indicating the chromosomal area to which a gene underlying the development of MM could be assigned according to the Knudson two-hit hypothesis. We found losses at 1p, 6q. 9p. 13q, and 14q. The copy number changes were very similar to those reported in sporadic cases. Our findings and results from sporadic cases highlight the importance of cloning the genes in the loss sites at 1p, 6q, 14q, and 22q. (C) 2001 Elsevier Science Inc. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
