5-S-cysteinyl-dopa (cysdopa) and 5-S-cysteinyl-dopamine (cysdopamine) are oxidized in vitro by soybean lipoxygenase (LOX) in the presence of hydrogen peroxide giving rise to the corresponding pheomelanins. The reaction is activated by caffeic acid and other catechols, suggesting a cofactor role for these compounds. The activating effect is proportional to the concentration of the cofactor, with a saturation profile. The activation extent of the various cofactors is directly related to LOX affinity for the same compounds. The possible implications of the peroxidative action of LOX in Parkinson's disease and in aging are discussed.
Pheomelanin production by the lipoxygenase-catalyzed oxidation of 5-S-cysteinyl-dopa and 5-S-cysteinyl-dopamine / Mosca, Luciana; C., Foppoli; Coccia, Raffaella; Rosei, Maria Anna. - In: PIGMENT CELL RESEARCH. - ISSN 0893-5785. - 9:(1996), pp. 117-125. [10.1111/j.1600-0749.1996.tb00099.x]
Pheomelanin production by the lipoxygenase-catalyzed oxidation of 5-S-cysteinyl-dopa and 5-S-cysteinyl-dopamine
MOSCA, Luciana;COCCIA, Raffaella;ROSEI, Maria Anna
1996
Abstract
5-S-cysteinyl-dopa (cysdopa) and 5-S-cysteinyl-dopamine (cysdopamine) are oxidized in vitro by soybean lipoxygenase (LOX) in the presence of hydrogen peroxide giving rise to the corresponding pheomelanins. The reaction is activated by caffeic acid and other catechols, suggesting a cofactor role for these compounds. The activating effect is proportional to the concentration of the cofactor, with a saturation profile. The activation extent of the various cofactors is directly related to LOX affinity for the same compounds. The possible implications of the peroxidative action of LOX in Parkinson's disease and in aging are discussed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.