Selective protein kinase C inhibitors can either block or significantly reduce Epstein-Barr virus infectivity: inhibition of transformation and decreased 3H-thymidine (3H-TdR) incorporation in human B lymphocytes infected with B95-8 EBV, as well as a significant reduction in the induction of early antigens in Raji cells superinfected by P3HRI EBV was achieved by pre-treating the cells with the inhibitors. The inhibitors do not act by blocking binding of the virus to its cellular receptor CR 2, but rather are effective in the viral internalization process. Our results suggest that protein kinase C may be involved in the process of viral entry into cells.
Epstein-Barr virus internalization and infectivity are blocked by selective protein kinase C inhibitors / Cirone, Mara; Angeloni, Antonio; Giuseppe, Barile; Zompetta, Claudia; Marco, Venanzoni; Torrisi, Maria Rosaria; Frati, Luigi; Faggioni, Alberto. - In: INTERNATIONAL JOURNAL OF CANCER. - ISSN 0020-7136. - STAMPA. - 45:(1990), pp. 490-493. [10.1002/ijc.2910450320]
Epstein-Barr virus internalization and infectivity are blocked by selective protein kinase C inhibitors
CIRONE, Mara;ANGELONI, Antonio;ZOMPETTA, Claudia;TORRISI, Maria Rosaria;FRATI, Luigi;FAGGIONI, Alberto
1990
Abstract
Selective protein kinase C inhibitors can either block or significantly reduce Epstein-Barr virus infectivity: inhibition of transformation and decreased 3H-thymidine (3H-TdR) incorporation in human B lymphocytes infected with B95-8 EBV, as well as a significant reduction in the induction of early antigens in Raji cells superinfected by P3HRI EBV was achieved by pre-treating the cells with the inhibitors. The inhibitors do not act by blocking binding of the virus to its cellular receptor CR 2, but rather are effective in the viral internalization process. Our results suggest that protein kinase C may be involved in the process of viral entry into cells.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.