Acta Diabetologica Volume 30, Issue 3, September 1993, Pages 138-142 A charge selectivity impairment in protein permselectivity is present in type 2 diabetes (Article) Morano, S.a, Pietravalle, P.a, De Rossi, M.G.a, Mariani, G.a, Cristina, G.a, Medici, F.a, Sensi, M.a, Andreani, D.a, Di Mario, U.b a Istituto di Clinica Medica 2 (Endocrinologia), University 'La Sapienza', Rome, Italy b Department of Clinical and Experimental Medicine, University of RC-Catanzaro, Catanzaro, Italy View references (27) Abstract A possible loss in kidney charge permselectivity of proteins before any manifestation of nephropathy has been sought in type 2 (non-insulin-dependent) diabetes by assessing the clearances of proteins differing in charge and/or size (anionic and cationic immunoglobulins, albumin). Eighty-five consecutive outpatients with type 2 diabetes were studied and compared with 101 normal subjects. Of the patients, 14.1% wree microalbuminuric and 2.3% macroalbuminuric. A significant increase in protein clearances was observed in diabetic patients in comparison with normal subjects: the median of albumin clearance was 0.09 ml/min, interquartile range (IR) 0.04-0.31 (P<0.01 vs normals); that of anionic immunoglobulins (IgG4) 0.02 ml/min, IR 0.01-0.05 (P<0.005 vs normals); and that of neutral/cationic immunoglobulins (IgG) 0.13 ml/min, IR 0.07-0.19 (P<0.01 vs normals). The anionic/cationic immunoglobulin ratio median was 0.22, IR 0.11-0.43, and exceeded the upper limit of normal values in 29.4% of all patients. IgG4 clearance was positively correlated with albumin clearance (r=0.72) and with IgG clearance (r=0.98). Nevertheless anionic immunoglobulin clearance was increased in a number of patients (17.3%) with normal IgG excretion and even in patiens (15.1%) with normal albumin clearance. Clearances of IgG4 and IgG, but not that of albumin, were correlated with the duration of diabetes. Thus, an increased anionic/cationic IgG ratio in type 2 diabetes highlights a charge selectivity defect in protein permselectivity; this selective proteinuria may reflect more accurately than does microalbuminuria an early kidney abnormality in this form of diabetes.

A charge selectivity impairment in protein permselectivity is present in type 2 diabetes / Morano, Susanna; Pietravalle, P; De Rossi, M. G; Mariani, G; Cristina, G; Medici, F; Sensi, Maurizio; Andreani, Domenico; Di Mario, U.. - In: ACTA DIABETOLOGICA. - ISSN 0940-5429. - STAMPA. - 30:3(1993), pp. 138-142. [10.1007/BF00572857]

A charge selectivity impairment in protein permselectivity is present in type 2 diabetes.

MORANO, Susanna;SENSI, Maurizio;ANDREANI, Domenico;
1993

Abstract

Acta Diabetologica Volume 30, Issue 3, September 1993, Pages 138-142 A charge selectivity impairment in protein permselectivity is present in type 2 diabetes (Article) Morano, S.a, Pietravalle, P.a, De Rossi, M.G.a, Mariani, G.a, Cristina, G.a, Medici, F.a, Sensi, M.a, Andreani, D.a, Di Mario, U.b a Istituto di Clinica Medica 2 (Endocrinologia), University 'La Sapienza', Rome, Italy b Department of Clinical and Experimental Medicine, University of RC-Catanzaro, Catanzaro, Italy View references (27) Abstract A possible loss in kidney charge permselectivity of proteins before any manifestation of nephropathy has been sought in type 2 (non-insulin-dependent) diabetes by assessing the clearances of proteins differing in charge and/or size (anionic and cationic immunoglobulins, albumin). Eighty-five consecutive outpatients with type 2 diabetes were studied and compared with 101 normal subjects. Of the patients, 14.1% wree microalbuminuric and 2.3% macroalbuminuric. A significant increase in protein clearances was observed in diabetic patients in comparison with normal subjects: the median of albumin clearance was 0.09 ml/min, interquartile range (IR) 0.04-0.31 (P<0.01 vs normals); that of anionic immunoglobulins (IgG4) 0.02 ml/min, IR 0.01-0.05 (P<0.005 vs normals); and that of neutral/cationic immunoglobulins (IgG) 0.13 ml/min, IR 0.07-0.19 (P<0.01 vs normals). The anionic/cationic immunoglobulin ratio median was 0.22, IR 0.11-0.43, and exceeded the upper limit of normal values in 29.4% of all patients. IgG4 clearance was positively correlated with albumin clearance (r=0.72) and with IgG clearance (r=0.98). Nevertheless anionic immunoglobulin clearance was increased in a number of patients (17.3%) with normal IgG excretion and even in patiens (15.1%) with normal albumin clearance. Clearances of IgG4 and IgG, but not that of albumin, were correlated with the duration of diabetes. Thus, an increased anionic/cationic IgG ratio in type 2 diabetes highlights a charge selectivity defect in protein permselectivity; this selective proteinuria may reflect more accurately than does microalbuminuria an early kidney abnormality in this form of diabetes.
1993
01 Pubblicazione su rivista::01a Articolo in rivista
A charge selectivity impairment in protein permselectivity is present in type 2 diabetes / Morano, Susanna; Pietravalle, P; De Rossi, M. G; Mariani, G; Cristina, G; Medici, F; Sensi, Maurizio; Andreani, Domenico; Di Mario, U.. - In: ACTA DIABETOLOGICA. - ISSN 0940-5429. - STAMPA. - 30:3(1993), pp. 138-142. [10.1007/BF00572857]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/246975
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 11
social impact