Although ample research has described the toxic effects of the metal beryllium on the respiratory apparatus, less is known about its effects on the vascular apparatus, including pulmonary blood vessels, We investigated the in vitro effects of beryllium on endothelial vascular adenosine diphosphatase activity and prostacyclin production in bovine aortic endothelium, and on nitric oxide release in isolated rabbit arteries, Rabbit and human platelet responsiveness was also evaluated, Beryllium inhibited vascular endothelial adenosine diphosphatase activity, prostacyclin production, and nitric oxide release, thus inducing functional alterations in vascular endothelial cells, It also induced platelet hyperreactivity to arachidonic acid, as shown by a lowering of the threshold of aggregating concentration and by concurrently increasing thromboxane production, In contrast, beryllium left the response to aggregating and nonaggregating concentrations of ADP and collagen unchanged, These findings show that beryllium may impair some vascular endothelial functions and alter the interaction between platelet and endothelial mediators. (C) 1997 Academic Press.

Toxicological effects of beryllium on platelets and vascular endothelium / Togna, Giuseppina Ines; Togna, Anna Rita; Pierluigi, Russo; Caprino, Luciano. - In: TOXICOLOGY AND APPLIED PHARMACOLOGY. - ISSN 0041-008X. - STAMPA. - 144:2(1997), pp. 262-267. [10.1006/taap.1997.8127]

Toxicological effects of beryllium on platelets and vascular endothelium

TOGNA, Giuseppina Ines;TOGNA, Anna Rita;CAPRINO, Luciano
1997

Abstract

Although ample research has described the toxic effects of the metal beryllium on the respiratory apparatus, less is known about its effects on the vascular apparatus, including pulmonary blood vessels, We investigated the in vitro effects of beryllium on endothelial vascular adenosine diphosphatase activity and prostacyclin production in bovine aortic endothelium, and on nitric oxide release in isolated rabbit arteries, Rabbit and human platelet responsiveness was also evaluated, Beryllium inhibited vascular endothelial adenosine diphosphatase activity, prostacyclin production, and nitric oxide release, thus inducing functional alterations in vascular endothelial cells, It also induced platelet hyperreactivity to arachidonic acid, as shown by a lowering of the threshold of aggregating concentration and by concurrently increasing thromboxane production, In contrast, beryllium left the response to aggregating and nonaggregating concentrations of ADP and collagen unchanged, These findings show that beryllium may impair some vascular endothelial functions and alter the interaction between platelet and endothelial mediators. (C) 1997 Academic Press.
1997
01 Pubblicazione su rivista::01a Articolo in rivista
Toxicological effects of beryllium on platelets and vascular endothelium / Togna, Giuseppina Ines; Togna, Anna Rita; Pierluigi, Russo; Caprino, Luciano. - In: TOXICOLOGY AND APPLIED PHARMACOLOGY. - ISSN 0041-008X. - STAMPA. - 144:2(1997), pp. 262-267. [10.1006/taap.1997.8127]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/246793
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