An endogenous ACE activator has been revealed. Neutrophil-enriched human leucocyte preparations released in isotonic media a relatively thermostable factor, capable of increasing the angiotensin-converting enzyme activity 1,6 - 2,0-fold. Activator would not pass through a 30 kDa cutoff membrane. Data on the presence of the activator in vivo were obtained in studies of protein-free serum fractions of patients with a hereditary CI-esterase inhibitor deficiency. It was suggested that the neutrophil-released ACE activator could have a role in the modulation of the inflammatory response.
ANGIOTENSIN-CONVERTING ENZYME ACTIVATOR FROM PURIFIED HUMAN NEUTROPHILS / Y. U. E., Elisseeva; L. V., Pavlikhina; T. V., Shavghulidze; Messina, Elisa; Giacomello, Alessandro; Salerno, Costantino; R., Perricone. - In: BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL. - ISSN 1039-9712. - STAMPA. - 30:4(1993), pp. 665-673.
ANGIOTENSIN-CONVERTING ENZYME ACTIVATOR FROM PURIFIED HUMAN NEUTROPHILS
MESSINA, ELISA;GIACOMELLO, Alessandro;SALERNO, Costantino;
1993
Abstract
An endogenous ACE activator has been revealed. Neutrophil-enriched human leucocyte preparations released in isotonic media a relatively thermostable factor, capable of increasing the angiotensin-converting enzyme activity 1,6 - 2,0-fold. Activator would not pass through a 30 kDa cutoff membrane. Data on the presence of the activator in vivo were obtained in studies of protein-free serum fractions of patients with a hereditary CI-esterase inhibitor deficiency. It was suggested that the neutrophil-released ACE activator could have a role in the modulation of the inflammatory response.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
