The hepatorenal syndrome is characterized, in essence, for progressive renal failure in a patient with advanced-stage liver disease and portal hypertension. The other features are: · Absence of an identifiable cause with only renal · Activation of endogenous vasoactive systems · Abnormalities of the arterial circulation with vasodilation system splacnico associated with vasoconstriction of the brachial artery, femoral and renal function. The renal artery vasoconstriction causes a speed reduction of glomerular filtration rate. Hemodynamic abnormalities and renal disease. In HRS there is an increase in cardiac output more than 10 liters / minute with reduction in systemic vascular resistance, often less than 500 dynes s / cm, reduction in blood pressure and increase in renal vascular resistance due to vasoconstriction of the renal artery with subsequent reduction in renal blood flow (RBF) and GFR
A new therapeutic approach to epatorenal syndrome / Cacciafesta, Mauro; Bonavita, S; Ferri, C; Piccirillo, Gianfranco; Ettorre, Evaristo; Marigliano, Vincenzo; Santucci, A; Balsano, F.. - In: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL. - ISSN 0011-393X. - 50:(1991), pp. 888-895.
A new therapeutic approach to epatorenal syndrome
CACCIAFESTA, Mauro;PICCIRILLO, Gianfranco;ETTORRE, Evaristo;MARIGLIANO, Vincenzo;
1991
Abstract
The hepatorenal syndrome is characterized, in essence, for progressive renal failure in a patient with advanced-stage liver disease and portal hypertension. The other features are: · Absence of an identifiable cause with only renal · Activation of endogenous vasoactive systems · Abnormalities of the arterial circulation with vasodilation system splacnico associated with vasoconstriction of the brachial artery, femoral and renal function. The renal artery vasoconstriction causes a speed reduction of glomerular filtration rate. Hemodynamic abnormalities and renal disease. In HRS there is an increase in cardiac output more than 10 liters / minute with reduction in systemic vascular resistance, often less than 500 dynes s / cm, reduction in blood pressure and increase in renal vascular resistance due to vasoconstriction of the renal artery with subsequent reduction in renal blood flow (RBF) and GFRI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.