In phytohemagglutinin (PHA) activated human peripheral blood mononuclear cells, [H-3]thymidine uptake and interferon gamma production were increased by the delta-opioid receptor agonist, deltorphin-I (10(-14)-10(-10) M) and by the delta-opioid antagonist naltrindole (10(-13)-10(-9) M). Combination of 10(-9) M naltrindole with deltorphin-I (10(-12)-10(-8) M) significantly inhibited the proliferative response but did not affect interferon production. (C) 1997 Elsevier Science B.V.
Immunomodulatory responses to delta-opioid receptor ligands in human lymphocytes / Noviello, Lia; S., Papadia; M. R., Capobianchi; Negri, Lucia. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - STAMPA. - 332:(1997), pp. R1-2. [10.1016/S0014-2999(97)01123-0]
Immunomodulatory responses to delta-opioid receptor ligands in human lymphocytes
NOVIELLO, Lia;NEGRI, Lucia
1997
Abstract
In phytohemagglutinin (PHA) activated human peripheral blood mononuclear cells, [H-3]thymidine uptake and interferon gamma production were increased by the delta-opioid receptor agonist, deltorphin-I (10(-14)-10(-10) M) and by the delta-opioid antagonist naltrindole (10(-13)-10(-9) M). Combination of 10(-9) M naltrindole with deltorphin-I (10(-12)-10(-8) M) significantly inhibited the proliferative response but did not affect interferon production. (C) 1997 Elsevier Science B.V.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
