Background. Many pathogens may be responsible of Non Gonococcal Urethritis (NGU) with the possible occurrence of symptomatic and asymptomatic mixed viral and bacterial infections. In particular, genital papillomaviruses (HPVs) have been searched since they are linked to both benign and malignant lesions of the penis and urethra and the presence of a potential male carried state has received limited scrutiny while the screening of sexually active females has received substantial attention. Methods. In male patients affected by chronic NGU, the presence of DNA of Chlamydia trachomatis, herpes simplex virus (HSV) type 1 and 2 and human papillomaviruses by PCR and the occurrence of Gram positive and Gram negative microrganisms, of Mycoplasma hominis and Ureaplasma urealyticum, by conventional cultural methods have been investigated. Results. Results obtained indicated a high percentage of mixed infections, up to 36%. Genital HPV DNA was detected in 31% of specimens positive for two or more agents, and HSV DNA was detected in 10% of studied population. Conclusions. The concomitant presence of different infectious agents could determine latent, sub-clinical or chronic infections with periodic reactivation. In particular results suggest that HPV and HSV may stimulate cytokine production which can up regulate the expression of other infectious agents and may be responsible for latent chlamydial infections characterised by the persistence of this microrganism in an altered form, viable but in a culture negative state. Therefore an increased awareness of mixed infections is relevant to define the management and treatment of chronic urethritis.

Simultaneous detection of HPV and other sexually transmitted agents in chronic urethritis / Chiarini, Fernanda; S., Pisani; C., Gallinelli; E., Papi; L., Seganti; Degener, Anna Marta; Pierangeli, Alessandra; Gentile, Vincenzo; S., Brunori; DI SILVERIO, Franco. - In: MINERVA UROLOGICA E NEFROLOGICA. - ISSN 0393-2249. - 50:4(1998), pp. 225-231.

Simultaneous detection of HPV and other sexually transmitted agents in chronic urethritis

CHIARINI, Fernanda;DEGENER, Anna Marta;PIERANGELI, Alessandra;GENTILE, Vincenzo;DI SILVERIO, Franco
1998

Abstract

Background. Many pathogens may be responsible of Non Gonococcal Urethritis (NGU) with the possible occurrence of symptomatic and asymptomatic mixed viral and bacterial infections. In particular, genital papillomaviruses (HPVs) have been searched since they are linked to both benign and malignant lesions of the penis and urethra and the presence of a potential male carried state has received limited scrutiny while the screening of sexually active females has received substantial attention. Methods. In male patients affected by chronic NGU, the presence of DNA of Chlamydia trachomatis, herpes simplex virus (HSV) type 1 and 2 and human papillomaviruses by PCR and the occurrence of Gram positive and Gram negative microrganisms, of Mycoplasma hominis and Ureaplasma urealyticum, by conventional cultural methods have been investigated. Results. Results obtained indicated a high percentage of mixed infections, up to 36%. Genital HPV DNA was detected in 31% of specimens positive for two or more agents, and HSV DNA was detected in 10% of studied population. Conclusions. The concomitant presence of different infectious agents could determine latent, sub-clinical or chronic infections with periodic reactivation. In particular results suggest that HPV and HSV may stimulate cytokine production which can up regulate the expression of other infectious agents and may be responsible for latent chlamydial infections characterised by the persistence of this microrganism in an altered form, viable but in a culture negative state. Therefore an increased awareness of mixed infections is relevant to define the management and treatment of chronic urethritis.
1998
hpv; urethritis microbiology; human; papilloma virus; sexually transmitted diseases
01 Pubblicazione su rivista::01a Articolo in rivista
Simultaneous detection of HPV and other sexually transmitted agents in chronic urethritis / Chiarini, Fernanda; S., Pisani; C., Gallinelli; E., Papi; L., Seganti; Degener, Anna Marta; Pierangeli, Alessandra; Gentile, Vincenzo; S., Brunori; DI SILVERIO, Franco. - In: MINERVA UROLOGICA E NEFROLOGICA. - ISSN 0393-2249. - 50:4(1998), pp. 225-231.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/245487
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 9
  • ???jsp.display-item.citation.isi??? ND
social impact