Transgenic animals of the line 8 contain the WAP-SV-T transgene. Females of this line synthesise the SV40 T-antigen in mammary gland epithelial cells during pregnancy and the lactation period, All females are 'milk-less' and the offspring have to be nursed by foster mothers, The reason for this phenomenon is a premature apoptosis during late pregnancy, Nonetheless a significant number of mammary epithelial cells escape apoptosis and all transgenic females develop breast cancer after the first lactation period.

The SV40 T-antigen induces premature apoptotic mammary gland involution during late pregnancy in transgenic mice / Y. J., Tzeng; K., Gottlob; Santarelli, Roberta; A., Graessmann. - In: FEBS LETTERS. - ISSN 0014-5793. - 380:3(1996), pp. 215-218. [10.1016/0014-5793(96)00021-x]

The SV40 T-antigen induces premature apoptotic mammary gland involution during late pregnancy in transgenic mice

SANTARELLI, Roberta;
1996

Abstract

Transgenic animals of the line 8 contain the WAP-SV-T transgene. Females of this line synthesise the SV40 T-antigen in mammary gland epithelial cells during pregnancy and the lactation period, All females are 'milk-less' and the offspring have to be nursed by foster mothers, The reason for this phenomenon is a premature apoptosis during late pregnancy, Nonetheless a significant number of mammary epithelial cells escape apoptosis and all transgenic females develop breast cancer after the first lactation period.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/245166
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