The enantiomers of cyclic trans-1,2-diols (trans-1,2-cyclohexanediol, 1,2-cycloheptanediol) were sepd., as their bis(3,5-dinitrophenyl)carbamates, by HPLC on a silica bound two-armed chiral receptor. Retention of the enantiomers of six and seven membered diols showed unusual response to temp. changes in the 25-85°C range. The anomalous variation of retention with temp. led, for cyclohexane- and cycloheptanediols, to a reversal of the elution order above 65° and 75°, resp. The effects were obsd. with CHCl3/MeOH mobile phases and were absent with AcOEt or ACN as polar additives.
Temperature dependent elution order of enantiomers on a two-armed receptor HPLC chiral stationary phase / Gasparrini, Francesco; F., Marini; Misiti, Domenico; Pierini, Marco; Villani, Claudio. - In: ENANTIOMER. - ISSN 1024-2430. - STAMPA. - 4:(1999), pp. 325-332.
Temperature dependent elution order of enantiomers on a two-armed receptor HPLC chiral stationary phase
GASPARRINI, Francesco;MISITI, Domenico;PIERINI, MARCO;VILLANI, Claudio
1999
Abstract
The enantiomers of cyclic trans-1,2-diols (trans-1,2-cyclohexanediol, 1,2-cycloheptanediol) were sepd., as their bis(3,5-dinitrophenyl)carbamates, by HPLC on a silica bound two-armed chiral receptor. Retention of the enantiomers of six and seven membered diols showed unusual response to temp. changes in the 25-85°C range. The anomalous variation of retention with temp. led, for cyclohexane- and cycloheptanediols, to a reversal of the elution order above 65° and 75°, resp. The effects were obsd. with CHCl3/MeOH mobile phases and were absent with AcOEt or ACN as polar additives.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
