Objective: To report the prevalence of age-related maculopathy (ARM) in Salandra, a small, isolated southern Italian community, to test the hypothesis that an environmental factor, scarce in such a remote community but ubiquitous in modern industrial societies, might modify the risk of developing ARM. Design: Population-based cross-sectional survey. Main Outcome Measures: Prevalence of advanced age-related macular degeneration (ARMD) (geographic atrophy or exudative maculopathy) and ARM (large, soft drusen or retinal pigment epithelium changes, or both) defined by fundus biomicroscopy and 30 degrees stereoscopic macular photography. Self-sustenance was assessed by interview of participants and local shop retailers. The degree of genetic isolation was computed using a model that fits the genetic population structure with the frequency distribution of surnames in the community. Results: A full ophthalmic examination was undertaken in 366 (63.5%) of 576 eligible participants, 354 (96.7%) of whom had clinical or photographic assessment for the presence of ARMD and 310 (84.6%) of whom had drusen characteristics graded on color transparencies for ARM. The overall prevalence of ARMD was 1.1%. Drusen larger than 50 mu m and more numerous than 10 were found in 4.5% of subjects. Salandra was the birthplace of 87.2% of participants and for 77.3% of bo th parents of each subject. People in the community tended to consume homegrown products. Conclusion: The prevalence of ARM may be lower in this self-sustained farming community than elsewhere in the industrialized world.

Age-related macular disease in rural southern Italy / S., Pagliarini; Moramarco, Antonietta; R. P., Wormald; B., Piguet; C., Carresi; BALACCO GABRIELI, Corrado; K. S., Sehmi; A. C., Bird. - In: ARCHIVES OF OPHTHALMOLOGY. - ISSN 0003-9950. - STAMPA. - 115:5(1997), pp. 616-622.

Age-related macular disease in rural southern Italy

MORAMARCO, Antonietta;BALACCO GABRIELI, Corrado;
1997

Abstract

Objective: To report the prevalence of age-related maculopathy (ARM) in Salandra, a small, isolated southern Italian community, to test the hypothesis that an environmental factor, scarce in such a remote community but ubiquitous in modern industrial societies, might modify the risk of developing ARM. Design: Population-based cross-sectional survey. Main Outcome Measures: Prevalence of advanced age-related macular degeneration (ARMD) (geographic atrophy or exudative maculopathy) and ARM (large, soft drusen or retinal pigment epithelium changes, or both) defined by fundus biomicroscopy and 30 degrees stereoscopic macular photography. Self-sustenance was assessed by interview of participants and local shop retailers. The degree of genetic isolation was computed using a model that fits the genetic population structure with the frequency distribution of surnames in the community. Results: A full ophthalmic examination was undertaken in 366 (63.5%) of 576 eligible participants, 354 (96.7%) of whom had clinical or photographic assessment for the presence of ARMD and 310 (84.6%) of whom had drusen characteristics graded on color transparencies for ARM. The overall prevalence of ARMD was 1.1%. Drusen larger than 50 mu m and more numerous than 10 were found in 4.5% of subjects. Salandra was the birthplace of 87.2% of participants and for 77.3% of bo th parents of each subject. People in the community tended to consume homegrown products. Conclusion: The prevalence of ARM may be lower in this self-sustained farming community than elsewhere in the industrialized world.
age-related maculopathy (arm); retina disease; risk assessment; rural population
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Age-related macular disease in rural southern Italy / S., Pagliarini; Moramarco, Antonietta; R. P., Wormald; B., Piguet; C., Carresi; BALACCO GABRIELI, Corrado; K. S., Sehmi; A. C., Bird. - In: ARCHIVES OF OPHTHALMOLOGY. - ISSN 0003-9950. - STAMPA. - 115:5(1997), pp. 616-622.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/244406
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