A survey for antibodies to a recombinant small viral capsid antigen (sVCA) of human herpesvirus type 8 (HHV-8) was conducted in Sardinia, one of the world's highest incidence areas for classic Kaposi's sarcoma (KS), Prevalence of antibodies to HHV-8 sVCA was greatest in patients with KS (95%), followed by family members (39%) and a Sardinian control population age-and sex-matched to the relatives (11%). Within families, prevalence of antibodies was about equal among spouses, children, and siblings of KS patients, a finding that raises the possibilities of intrafamilial person-to-person or vertical transmission. Antibodies were detected 2-3 times more frequently in males than in females, The data show that prevalence of antibodies to HHV-8 sVCA correlates with the distribution of classic KS in a high-incidence area, Clustering of seroprevalence within some families suggests the presence of familial risk factors for active HHV-8 infection.
High prevalence of antibodies to Human Herpesvirus 8 in relatives of patients with classic Kaposi's sarcoma from Sardinia / Angeloni, A., Heston, L., Uccini, S., Sirianni, M.C., Cottoni, F., Masala, M.v., Cerimele, D., Lin, S.f., Sun, R., Rigsby, M., Faggioni, A., Miller, G.. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - STAMPA. - 177:(1998), pp. 1715-1718. [10.1086/517429 Published: JUN 1998]
High prevalence of antibodies to Human Herpesvirus 8 in relatives of patients with classic Kaposi's sarcoma from Sardinia.
ANGELONI, Antonio;UCCINI, Stefania;SIRIANNI, Maria Caterina;FAGGIONI, Alberto;
1998
Abstract
A survey for antibodies to a recombinant small viral capsid antigen (sVCA) of human herpesvirus type 8 (HHV-8) was conducted in Sardinia, one of the world's highest incidence areas for classic Kaposi's sarcoma (KS), Prevalence of antibodies to HHV-8 sVCA was greatest in patients with KS (95%), followed by family members (39%) and a Sardinian control population age-and sex-matched to the relatives (11%). Within families, prevalence of antibodies was about equal among spouses, children, and siblings of KS patients, a finding that raises the possibilities of intrafamilial person-to-person or vertical transmission. Antibodies were detected 2-3 times more frequently in males than in females, The data show that prevalence of antibodies to HHV-8 sVCA correlates with the distribution of classic KS in a high-incidence area, Clustering of seroprevalence within some families suggests the presence of familial risk factors for active HHV-8 infection.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
