Several lines of evidence have been accumulating indicating that an important role may be played by mitochondrial homeostasis in the initiation phase, the first stage of apoptosis, This work describes the results obtained by using different inhibitors of monoamine oxidases (MAO), i.e. paragyline, clorgyline and deprenyl, on mitochondrial integrity and apoptosis. Both pargyline and clorgyline are capable of protecting cells from apoptosis induced by serum starvation while deprenyl is ineffective. These data represent the first demonstration that MAO-A inhibitors may protect cells from apoptosis through a mechanism involving the maintenance of mitochondrial homeostasis, (C) 1998 Federation of European Biochemical Societies.

Protection against apoptosis by monoamine oxidase A inhibitors / W., Malorni; A. M., Giammarioli; P., Matarrese; Pietrangeli, Paola; Agostinelli, Enzo; A., Ciaccio; E., Grassilli; Mondovi', Bruno. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 426:1(1998), pp. 155-159. [10.1016/s0014-5793(98)00315-9]

Protection against apoptosis by monoamine oxidase A inhibitors

PIETRANGELI, Paola;AGOSTINELLI, Enzo;MONDOVI', Bruno
1998

Abstract

Several lines of evidence have been accumulating indicating that an important role may be played by mitochondrial homeostasis in the initiation phase, the first stage of apoptosis, This work describes the results obtained by using different inhibitors of monoamine oxidases (MAO), i.e. paragyline, clorgyline and deprenyl, on mitochondrial integrity and apoptosis. Both pargyline and clorgyline are capable of protecting cells from apoptosis induced by serum starvation while deprenyl is ineffective. These data represent the first demonstration that MAO-A inhibitors may protect cells from apoptosis through a mechanism involving the maintenance of mitochondrial homeostasis, (C) 1998 Federation of European Biochemical Societies.
1998
amine oxidase; apoptosis; mitochondrial membrane potential
01 Pubblicazione su rivista::01a Articolo in rivista
Protection against apoptosis by monoamine oxidase A inhibitors / W., Malorni; A. M., Giammarioli; P., Matarrese; Pietrangeli, Paola; Agostinelli, Enzo; A., Ciaccio; E., Grassilli; Mondovi', Bruno. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 426:1(1998), pp. 155-159. [10.1016/s0014-5793(98)00315-9]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/243791
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