Several lines of evidence have been accumulating indicating that an important role may be played by mitochondrial homeostasis in the initiation phase, the first stage of apoptosis, This work describes the results obtained by using different inhibitors of monoamine oxidases (MAO), i.e. paragyline, clorgyline and deprenyl, on mitochondrial integrity and apoptosis. Both pargyline and clorgyline are capable of protecting cells from apoptosis induced by serum starvation while deprenyl is ineffective. These data represent the first demonstration that MAO-A inhibitors may protect cells from apoptosis through a mechanism involving the maintenance of mitochondrial homeostasis, (C) 1998 Federation of European Biochemical Societies.
Protection against apoptosis by monoamine oxidase A inhibitors / W., Malorni; A. M., Giammarioli; P., Matarrese; Pietrangeli, Paola; Agostinelli, Enzo; A., Ciaccio; E., Grassilli; Mondovi', Bruno. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 426:1(1998), pp. 155-159. [10.1016/s0014-5793(98)00315-9]
Protection against apoptosis by monoamine oxidase A inhibitors
PIETRANGELI, Paola;AGOSTINELLI, Enzo;MONDOVI', Bruno
1998
Abstract
Several lines of evidence have been accumulating indicating that an important role may be played by mitochondrial homeostasis in the initiation phase, the first stage of apoptosis, This work describes the results obtained by using different inhibitors of monoamine oxidases (MAO), i.e. paragyline, clorgyline and deprenyl, on mitochondrial integrity and apoptosis. Both pargyline and clorgyline are capable of protecting cells from apoptosis induced by serum starvation while deprenyl is ineffective. These data represent the first demonstration that MAO-A inhibitors may protect cells from apoptosis through a mechanism involving the maintenance of mitochondrial homeostasis, (C) 1998 Federation of European Biochemical Societies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
