A family of bombinin-related peptides is present in the skin of Bombina variegata. These peptides contain 27 residues with Gly as N-terminus and display antimicrobial activity. From sequence analysis of the cDNAs encoding for the corresponding peptide precursors, the presence of a novel 20-residue peptide with Ile as N-terminus was predicted. We have now purified a family of hydrophobic peptides named H1-H5, whose sequences correspond to the predicted peptide with some variability in positions 1, 2 and 8. In particular, H3-H5 contain a D-alloisoleucine residue in the second position. All these peptides display antibacterial and haemolytic activity.

Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata / Mignogna, Giuseppina; Simmaco, Maurizio; Kreil, G; Barra, Donatella. - In: EMBO JOURNAL. - ISSN 0261-4189. - STAMPA. - 12:(1993), pp. 4829-4832.

Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata

MIGNOGNA, Giuseppina;SIMMACO, Maurizio;BARRA, Donatella
1993

Abstract

A family of bombinin-related peptides is present in the skin of Bombina variegata. These peptides contain 27 residues with Gly as N-terminus and display antimicrobial activity. From sequence analysis of the cDNAs encoding for the corresponding peptide precursors, the presence of a novel 20-residue peptide with Ile as N-terminus was predicted. We have now purified a family of hydrophobic peptides named H1-H5, whose sequences correspond to the predicted peptide with some variability in positions 1, 2 and 8. In particular, H3-H5 contain a D-alloisoleucine residue in the second position. All these peptides display antibacterial and haemolytic activity.
1993
D-ALLOISOLEUCINE,; D-AMINO ACIDS,; AMPHIBIAN SKIN,; ANTIBACTERIAL PEPTIDES,; BOMBINA-VARIEGATA,
01 Pubblicazione su rivista::01a Articolo in rivista
Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata / Mignogna, Giuseppina; Simmaco, Maurizio; Kreil, G; Barra, Donatella. - In: EMBO JOURNAL. - ISSN 0261-4189. - STAMPA. - 12:(1993), pp. 4829-4832.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/243713
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