The diagnostics of community-acquired acute HCV hepatitis in an endemic area was studied in 110 Egyptian patients with acute jaundice. In the first week of the jaundiced period 30 of 110 patients (27.3%) had anti-HCV antibodies. The majority already showed high levels of anti-HCV IgG (25/30), associated with anti-HCV IgM in nine of them. Five patients showed only an HCV IgM reactivity, Seven had also anti-HEV and/or anti-HBV: their jaundice could then be related to an acute infection caused by those viruses. All patients were infected with genotype 4a, in three associated with the 3a. During the follow-up five patients seroconverted for IgG, while their anti-HCV IgM did not show a uniform pattern of reactivity. Patients with positive serology suspected of an acute HCV infection were older than the patients with other acute hepatitis and showed a lower peak of ALT level, Seroconversion during acute hepatitis strongly indicated HCV as the etiologic agent. However, the detection of anti-HCV IgG antibodies in the jaundiced period showed that the majority of patients had already seroconverted to anti-HCV antibodies; in most of them it is possible to hypothesize a reactivation of a chronic HCV infection.

HCV infection in Egyptian patients with acute hepatitis / Quinti, Isabella; D., Elsalman; M. K., Monier; B. G., Hackbart; M. S., Darwish; D., Elzamiaty; R., Paganelli; F., Pandolfi; R. R., Arthur. - In: DIGESTIVE DISEASES AND SCIENCES. - ISSN 0163-2116. - STAMPA. - 42:10(1997), pp. 2017-2023. [10.1023/a:1018897813268]

HCV infection in Egyptian patients with acute hepatitis

QUINTI, Isabella;
1997

Abstract

The diagnostics of community-acquired acute HCV hepatitis in an endemic area was studied in 110 Egyptian patients with acute jaundice. In the first week of the jaundiced period 30 of 110 patients (27.3%) had anti-HCV antibodies. The majority already showed high levels of anti-HCV IgG (25/30), associated with anti-HCV IgM in nine of them. Five patients showed only an HCV IgM reactivity, Seven had also anti-HEV and/or anti-HBV: their jaundice could then be related to an acute infection caused by those viruses. All patients were infected with genotype 4a, in three associated with the 3a. During the follow-up five patients seroconverted for IgG, while their anti-HCV IgM did not show a uniform pattern of reactivity. Patients with positive serology suspected of an acute HCV infection were older than the patients with other acute hepatitis and showed a lower peak of ALT level, Seroconversion during acute hepatitis strongly indicated HCV as the etiologic agent. However, the detection of anti-HCV IgG antibodies in the jaundiced period showed that the majority of patients had already seroconverted to anti-HCV antibodies; in most of them it is possible to hypothesize a reactivation of a chronic HCV infection.
1997
acute hepatitis; anti-hcv antibodies; hepatitis c virus
01 Pubblicazione su rivista::01a Articolo in rivista
HCV infection in Egyptian patients with acute hepatitis / Quinti, Isabella; D., Elsalman; M. K., Monier; B. G., Hackbart; M. S., Darwish; D., Elzamiaty; R., Paganelli; F., Pandolfi; R. R., Arthur. - In: DIGESTIVE DISEASES AND SCIENCES. - ISSN 0163-2116. - STAMPA. - 42:10(1997), pp. 2017-2023. [10.1023/a:1018897813268]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/243416
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