We describe a simple method for measuring orotic acid and uracil concentration in urine by capillary zone electrophoresis in 20 mM Na-borate buffer, pH 9.2. The method was applied for studying a patient with HHH (hyperornithinemia, hyperammonemia and homocitrullinuria) syndrome. A high value of uracil excretion was found during periods of relatively low orotic acid excretion and normal ammonemia. The orotic acid level in urine was increased by increasing protein intake.

Determination of urinary orotic acid and uracil by capillary zone electrophoresis / Salerno, Costantino; D'Eufemia, Patrizia; M., Celli; R., Finocchiaro; Crifo', Carlo; Giardini, Omero. - In: JOURNAL OF CHROMATOGRAPHY B. BIOMEDICAL SCIENCES AND APPLICATIONS. - ISSN 1387-2273. - STAMPA. - 734:1(1999), pp. 175-178. [10.1016/s0378-4347(99)00337-0]

Determination of urinary orotic acid and uracil by capillary zone electrophoresis

SALERNO, Costantino;D'EUFEMIA, Patrizia;CRIFO', Carlo;GIARDINI, Omero
1999

Abstract

We describe a simple method for measuring orotic acid and uracil concentration in urine by capillary zone electrophoresis in 20 mM Na-borate buffer, pH 9.2. The method was applied for studying a patient with HHH (hyperornithinemia, hyperammonemia and homocitrullinuria) syndrome. A high value of uracil excretion was found during periods of relatively low orotic acid excretion and normal ammonemia. The orotic acid level in urine was increased by increasing protein intake.
orotic acid; ortic acid; uracil
01 Pubblicazione su rivista::01a Articolo in rivista
Determination of urinary orotic acid and uracil by capillary zone electrophoresis / Salerno, Costantino; D'Eufemia, Patrizia; M., Celli; R., Finocchiaro; Crifo', Carlo; Giardini, Omero. - In: JOURNAL OF CHROMATOGRAPHY B. BIOMEDICAL SCIENCES AND APPLICATIONS. - ISSN 1387-2273. - STAMPA. - 734:1(1999), pp. 175-178. [10.1016/s0378-4347(99)00337-0]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/243272
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