The aim of the study was to evaluate the possible changes in plasma adrenomedullin (AM) levels in patients with primary aldosteronism before and after surgical resection. The study included 13 patients affected by aldosterone-producing adenoma (9 women, 4 men; mean age 36.2 ± 14.2 years) and 20 healthy control subjects (7 women, 13 M; mean age 31.8 ± 12.4 years). Unilateral adrenalectomy was performed in all patients and adrenal mass consisted of a benign adrenal cortical adenoma. The mean plasma AM concentrations in patients with primary aldosteronism (36.2 ± 19.3 pg/ml) were significantly (p < 0.0001) higher than those of normal subjects (13.2 ± 6.2 pg/ml). In these patients the plasma AM levels significantly (p < 0.0001) reduced after surgical removal of the tumours (14.9 ± 7.6 pg/ml). In all patients with aldosterone-producing adenoma, tumour diameter correlated with the plasma AM concentrations (r = 0.631; p < 0.021). In conclusion, the present investigation shows that in primary aldosteronism due to adrenal adenoma plasma AM levels are higher at the moment of diagnosis and decline after successful adrenal operation.

Adrenomedullin levels are high in primary aldosteronism due to adenoma and decline after surgical cure / Letizia, Claudio; DE TOMA, Giorgio; S., Cerci; Massa, Rita; S., Coassin; S., Subioli; L., Scuro; A., De Ciocchis. - In: BLOOD PRESSURE. - ISSN 0803-7051. - 7:1(1998), pp. 19-23. [10.1080/080370598437529]

Adrenomedullin levels are high in primary aldosteronism due to adenoma and decline after surgical cure

LETIZIA, Claudio;DE TOMA, Giorgio;MASSA, Rita;
1998

Abstract

The aim of the study was to evaluate the possible changes in plasma adrenomedullin (AM) levels in patients with primary aldosteronism before and after surgical resection. The study included 13 patients affected by aldosterone-producing adenoma (9 women, 4 men; mean age 36.2 ± 14.2 years) and 20 healthy control subjects (7 women, 13 M; mean age 31.8 ± 12.4 years). Unilateral adrenalectomy was performed in all patients and adrenal mass consisted of a benign adrenal cortical adenoma. The mean plasma AM concentrations in patients with primary aldosteronism (36.2 ± 19.3 pg/ml) were significantly (p < 0.0001) higher than those of normal subjects (13.2 ± 6.2 pg/ml). In these patients the plasma AM levels significantly (p < 0.0001) reduced after surgical removal of the tumours (14.9 ± 7.6 pg/ml). In all patients with aldosterone-producing adenoma, tumour diameter correlated with the plasma AM concentrations (r = 0.631; p < 0.021). In conclusion, the present investigation shows that in primary aldosteronism due to adrenal adenoma plasma AM levels are higher at the moment of diagnosis and decline after successful adrenal operation.
1998
adrenomedullin; primary aldosteronism
01 Pubblicazione su rivista::01a Articolo in rivista
Adrenomedullin levels are high in primary aldosteronism due to adenoma and decline after surgical cure / Letizia, Claudio; DE TOMA, Giorgio; S., Cerci; Massa, Rita; S., Coassin; S., Subioli; L., Scuro; A., De Ciocchis. - In: BLOOD PRESSURE. - ISSN 0803-7051. - 7:1(1998), pp. 19-23. [10.1080/080370598437529]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/242926
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 19
  • ???jsp.display-item.citation.isi??? ND
social impact