The in vitro antiviral activity against picornaviruses (rhinovirus serotype 1B and 14, and poliovirus type 2) of new synthetic 3-hydroxyflavones, 3-acetoxyflavones, and substituted cinnamic and benzoic acid flavon-3-yl esters was evaluated. The maximum non-toxic concentration of compounds was determined in a human cell line (HeLa) suitable for the replication of the three viruses. Their antiviral potency was measured by a plaque reduction assay. Generally, rhinoviruses exhibited a higher sensitivity to the new flavonoids than poliovirus. Flavones, with sterically small substituents in position 3, showed good activity against both rhinoviruses tested. However, the introduction of bulky substituents in the same position resulted in analogues with a higher toxicity and often with a lower efficacy.

Anti-picornavirus activity of synthetic flavon-3-yl esters / Conti, Cinzia; Mastromarino, Paola; R., Sgro; Desideri, Nicoletta. - In: ANTIVIRAL CHEMISTRY & CHEMOTHERAPY. - ISSN 0956-3202. - 9:6(1998), pp. 511-515.

Anti-picornavirus activity of synthetic flavon-3-yl esters

CONTI, Cinzia;MASTROMARINO, Paola;DESIDERI, Nicoletta
1998

Abstract

The in vitro antiviral activity against picornaviruses (rhinovirus serotype 1B and 14, and poliovirus type 2) of new synthetic 3-hydroxyflavones, 3-acetoxyflavones, and substituted cinnamic and benzoic acid flavon-3-yl esters was evaluated. The maximum non-toxic concentration of compounds was determined in a human cell line (HeLa) suitable for the replication of the three viruses. Their antiviral potency was measured by a plaque reduction assay. Generally, rhinoviruses exhibited a higher sensitivity to the new flavonoids than poliovirus. Flavones, with sterically small substituents in position 3, showed good activity against both rhinoviruses tested. However, the introduction of bulky substituents in the same position resulted in analogues with a higher toxicity and often with a lower efficacy.
anti-poliovirus activity; anti-rhinovirus activity; flavonoids
01 Pubblicazione su rivista::01a Articolo in rivista
Anti-picornavirus activity of synthetic flavon-3-yl esters / Conti, Cinzia; Mastromarino, Paola; R., Sgro; Desideri, Nicoletta. - In: ANTIVIRAL CHEMISTRY & CHEMOTHERAPY. - ISSN 0956-3202. - 9:6(1998), pp. 511-515.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/242533
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