In the presence of hydrogen peroxide cytochrome c can perform the oxidation of catecholamines and their S-cysteinyl-derivatives yielding melanins as final products. The initial reaction rate is linearly dependent on cytochrome c and H2O2 concentration; the reaction follows the Michaelis and Menten kinetics both for H2O2 and hydrogen donors. Sulfhydryl compounds inhibit the formation of the pigment. The reported data indicate that a heme- containing protein belonging to the mitochondrial chain can accelerate the oxidation of catecholamines to eumelanins.
Production of melanin pigments by cytochrome c/H2O2 system / Rosei, Maria Anna; Blarzino, Carla; Coccia, Raffaella; Cesira, Foppoli; Mosca, Luciana; Cini, Chiara. - In: THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. - ISSN 1357-2725. - 30:4(1998), pp. 457-463. [10.1016/s1357-2725(98)00014-4]
Production of melanin pigments by cytochrome c/H2O2 system
ROSEI, Maria Anna;BLARZINO, Carla;COCCIA, Raffaella;MOSCA, Luciana;CINI, Chiara
1998
Abstract
In the presence of hydrogen peroxide cytochrome c can perform the oxidation of catecholamines and their S-cysteinyl-derivatives yielding melanins as final products. The initial reaction rate is linearly dependent on cytochrome c and H2O2 concentration; the reaction follows the Michaelis and Menten kinetics both for H2O2 and hydrogen donors. Sulfhydryl compounds inhibit the formation of the pigment. The reported data indicate that a heme- containing protein belonging to the mitochondrial chain can accelerate the oxidation of catecholamines to eumelanins.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
