In the presence of hydrogen peroxide cytochrome c can perform the oxidation of catecholamines and their S-cysteinyl-derivatives yielding melanins as final products. The initial reaction rate is linearly dependent on cytochrome c and H2O2 concentration; the reaction follows the Michaelis and Menten kinetics both for H2O2 and hydrogen donors. Sulfhydryl compounds inhibit the formation of the pigment. The reported data indicate that a heme- containing protein belonging to the mitochondrial chain can accelerate the oxidation of catecholamines to eumelanins.

Production of melanin pigments by cytochrome c/H2O2 system / Rosei, Maria Anna; Blarzino, Carla; Coccia, Raffaella; Cesira, Foppoli; Mosca, Luciana; Cini, Chiara. - In: THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. - ISSN 1357-2725. - 30:4(1998), pp. 457-463. [10.1016/s1357-2725(98)00014-4]

Production of melanin pigments by cytochrome c/H2O2 system

ROSEI, Maria Anna;BLARZINO, Carla;COCCIA, Raffaella;MOSCA, Luciana;CINI, Chiara
1998

Abstract

In the presence of hydrogen peroxide cytochrome c can perform the oxidation of catecholamines and their S-cysteinyl-derivatives yielding melanins as final products. The initial reaction rate is linearly dependent on cytochrome c and H2O2 concentration; the reaction follows the Michaelis and Menten kinetics both for H2O2 and hydrogen donors. Sulfhydryl compounds inhibit the formation of the pigment. The reported data indicate that a heme- containing protein belonging to the mitochondrial chain can accelerate the oxidation of catecholamines to eumelanins.
1998
catecholamines; cytochrome c; melanin; oxidation; pigment
01 Pubblicazione su rivista::01a Articolo in rivista
Production of melanin pigments by cytochrome c/H2O2 system / Rosei, Maria Anna; Blarzino, Carla; Coccia, Raffaella; Cesira, Foppoli; Mosca, Luciana; Cini, Chiara. - In: THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. - ISSN 1357-2725. - 30:4(1998), pp. 457-463. [10.1016/s1357-2725(98)00014-4]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/242531
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